Peripheral blood mononuclear cells (PBMCs) were isolated from a 57-year-old female who was clinically diagnosed as familial atrial fibrillation and were reprogrammed using non-integrative Sendai viral vectors containing reprogramming factors OCT4, SOX2, KLF4 and cMYC. The generated human induced pluripotent stem cell (hiPSC) line, ZZUSAHi001-A, exhibited a normal karyotype, showed robust expression of pluripotency markers and differentiated towards three germ layers in vivo.

中文翻译：

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产生源自携带 KCNA5 c.775G>A 突变的家族性房颤患者的患者特异性诱导多能干细胞 (ZZUSAHi001-A)。

从一名临床诊断为家族性房颤的 57 岁女性中分离外周血单核细胞 (PBMC)，并使用含有重编程因子 OCT4、SOX2、KLF4 和 cMYC 的非整合型仙台病毒载体进行重编程。生成的人诱导多能干细胞 (hiPSC) 系 ZZUSAHi001-A 表现出正常的核型，表现出多能性标记的强劲表达，并在体内分化为三个胚层。