In the current study, to support the safety pharmacology assessment of Ethanamizuril as a new potent anticoccidial agent of triazine compounds, the effects of Ethanamizuril on the central nervous system, cardiovascular system and respiratory system were investigated. Using locomotor activity test, climbing behavior test and nembutal subthreshold hypnotic test at each time point after oral administration of Ethanamizuril to mice, the effects on the central nervous system were evaluated. An assessment of Ethanamizuril effects on the cardiovascular and respiratory system were performed by the use of a telemetry system in conscious beagle dogs. The results showed that the treatment of Ethanamizuril had no effects on motor activity, behavioral changes, coordination, and sensory/motor reflex responses in mice. There were also no changes in heart rate, blood pressure, and electrocardiogram at all doses and each time points in beagle dogs. Our data suggested that Ethanamizuril showed no adverse effects on the central nervous system, cardiovascular system, and respiratory system.

在当前的研究中，为支持乙胺嘧啶作为一种新的有效的三嗪类抗球虫药的安全药理学评估，研究了乙胺嘧啶对中枢神经系统，心血管系统和呼吸系统的影响。在对小鼠口服乙胺苯咪唑后的每个时间点，使用运动活动测试，攀爬行为测试和门槛亚阈下催眠测试，评估其对中枢神经系统的影响。使用遥测系统在有意识的比格犬中评估乙草胺对心血管和呼吸系统的作用。结果表明，乙胺嘧啶的治疗对小鼠的运动活动，行为变化，协调以及感觉/运动反射反应没有影响。心率也没有变化，比格犬的所有剂量和每个时间点的血压和心电图。我们的数据表明乙胺嘧啶对中枢神经系统，心血管系统和呼吸系统没有不良影响。