Amomutsaokols A–K, diarylheptanoids from Amomum tsao-ko and their α-glucosidase inhibitory activity,Phytochemistry

当前位置： X-MOL 学术 › Phytochemistry › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Amomutsaokols A–K, diarylheptanoids from Amomum tsao-ko and their α-glucosidase inhibitory activity
Phytochemistry ( IF 3.2 ) Pub Date : 2020-09-01 , DOI: 10.1016/j.phytochem.2020.112418
Xiao-Feng He ₁ , Hui-Mei Wang ₂ , Chang-An Geng ₃ , Jing Hu ₃ , Xue-Mei Zhang ₃ , Yuan-Qiang Guo ₂ , Ji-Jun Chen ₁

Affiliation

Eleven undescribed diarylheptanoids, amomutsaokols A‒K (1-11), together with 13 known ones (13-24), were isolated from the active fraction of the fruits of Amomum tsao-ko. The structures of the undescribed compounds were determined by extensive 1D and 2D NMR, HRESIMS and ECD calculations. Compounds 3-5, 7, 8, 12, 14 and 19 showed obviously α-glucosidase inhibitory activity with IC50 values ranging from 12.9 to 48.8 μM. An enzyme kinetic analysis indicated that compounds 8 and 9 were α-glucosidase noncompetitive inhibitors with Ki values of 18.5 and 213.0 μM, respectively. This study supported diarylheptanoids as the active constituents of A. tsao-ko with α-glucosidase inhibitory effects.

中文翻译：

Amomutsaokols A-K，来自砂仁的二芳基庚烷类化合物及其α-葡萄糖苷酶抑制活性

从砂仁果的活性成分中分离出 11 种未描述的二芳基庚烷类化合物 amomutsaokols A-K (1-11) 以及 13 种已知化合物 (13-24)。未描述的化合物的结构通过广泛的 1D 和 2D NMR、HRESIMS 和 ECD 计算确定。化合物3-5、7、8、12、14和19表现出明显的α-葡萄糖苷酶抑制活性，IC50值为12.9-48.8 μM。酶动力学分析表明，化合物 8 和 9 是 α-葡萄糖苷酶非竞争性抑制剂，Ki 值分别为 18.5 和 213.0 μM。该研究支持二芳基庚烷类化合物作为草蒿的活性成分，具有 α-葡萄糖苷酶抑制作用。

更新日期：2020-09-01

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11