Delirium, the clinical expression of acute encephalopathy, is a common neuropsychiatric syndrome that is related to poor outcomes, such as long-term cognitive impairment. Disturbances of functional brain networks are hypothesized to predispose for delirium. The aim of this study in non-delirious elderly individuals was to investigate whether predisposing risk factors for delirium are associated with fMRI network characteristics that have been observed during delirium. As predisposing risk factors, we studied age, alcohol misuse, cognitive impairment, depression, functional impairment, history of transient ischemic attack or stroke, and physical status. In this multicenter study, we included 554 subjects and analyzed resting-state fMRI data from 222 elderly subjects (63% male, age range: 65–85 year) after rigorous motion correction. Functional network characteristics were analyzed and based on the minimum spanning tree (MST). Global functional connectivity strength, network efficiency (MST diameter) and network integration (MST leaf fraction) were analyzed, as these measures were altered during delirium in previous studies. Linear regression analyses were used to investigate the relation between predisposing delirium risk factors and delirium-related fMRI characteristics, adjusted for confounding and multiple testing. Predisposing risk factors for delirium were not associated with delirium-related fMRI network characteristics. Older age within our elderly cohort was related to global functional connectivity strength (β = 0.182, p < 0.05), but in the opposite direction than hypothesized. Delirium-related functional network impairments can therefore not be considered as the common mechanism for predisposition for delirium.

r妄是急性脑病的临床表现，是一种常见的神经精神病综合症，与不良结局（例如长期认知障碍）有关。据推测，功能性大脑网络的紊乱易诱发del妄。这项针对非精神错乱的老年人的研究的目的是调查investigate妄的易感危险因素是否与del妄期间观察到的fMRI网络特征有关。作为诱发因素，我们研究了年龄，酒精滥用，认知障碍，抑郁，功能障碍，短暂性脑缺血发作或中风的病史以及身体状况。在这项多中心研究中，我们纳入了554名受试者，并分析了经过严格运动校正后的222名老年受试者（63％的男性，年龄范围：65-85岁）的静息状态fMRI数据。对功能网络特性进行了分析，并基于最小生成树（MST）。分析了全局功能连接强度，网络效率（MST直径）和网络集成（MST叶分数），因为在以前的研究中del妄期间这些措施已更改。线性回归分析用于调查易患的ir妄危险因素与del妄相关的fMRI特征之间的关系，并对其进行了调整以进行混淆和多重测试。del妄的易感危险因素与ir妄相关的fMRI网络特征无关。我们老年队列中的老年人年龄与整体功能连接强度有关（β= 0.182，p <0.05），但与假设的方向相反。