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Plasmonics meets super-resolution microscopy in biology.
Micron ( IF 2.5 ) Pub Date : 2020-07-15 , DOI: 10.1016/j.micron.2020.102916
Miaoyan Wang 1 , Meiqi Li 1 , Shan Jiang 1 , Juntao Gao 2 , Peng Xi 1
Affiliation  

Super-resolution microscopy can reveal the subtle biological processes hidden behind the optical diffraction barrier. Plasmonics is a key nanophotonic that combines electronics and photonics through the interaction of light with the metallic nanostructure. In this review, we survey the recent progresses on plasmonic-assisted super-resolution microscopy. The strong electromagnetic field enhancement trapped near metallic nanostructures offers a unique opportunity to manipulate the illumination scheme for overcoming the diffraction limit. Plasmonic nanoprobes, exploited as surface-enhanced Raman scattering (SERS) and plasmon-enhanced fluorescence nanoparticles, are a major category of contrast agent in super-resolution microscopy. The outstanding challenges, future developments, and potential biological applications are also discussed.



中文翻译:

等离子体与生物学中的超分辨率显微镜相结合。

超分辨率显微镜可以揭示隐藏在光学衍射屏障后面的微妙生物过程。等离子体是一种关键的纳米光子学,它通过光与金属纳米结构的相互作用将电子学和光子学结合起来。在这篇综述中,我们调查了等离子体辅助超分辨率显微镜的最新进展。金属纳米结构附近的强电磁场增强为操纵照明方案以克服衍射极限提供了独特的机会。等离子纳米探针被用作表面增强拉曼散射 (SERS) 和等离子增强荧光纳米粒子,是超分辨率显微镜中的主要造影剂类别。还讨论了突出的挑战、未来的发展和潜在的生物应用。

更新日期:2020-07-15
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