Perhaps the most recognizable consequences of tissue aging are manifested in the skin. Hair graying and loss, telltale wrinkles, and age spots are indicative of physiological aging symptoms, many of which are analogous to processes in other tissues as well with less visible outcomes. While the study of skin aging has been conducted for decades, more recent work has illuminated many of the fundamental molecular and physiological causes of aging in the skin. Recent technological advances have allowed for the detection and quantification of a variety of physiological triggers that lead to aging in the skin and molecular methods have begun to determine the etiology of these phenotypic features. This review will attempt to summarize recent work in this area and provide some speculation about the next wave of studies.

或许组织老化最明显的后果体现在皮肤上。头发灰白和脱落、明显的皱纹和老年斑是生理老化症状的表现，其中许多类似于其他组织中的过程，并且结果不太明显。虽然皮肤老化的研究已经进行了几十年，但最近的工作已经阐明了皮肤老化的许多基本分子和生理原因。最近的技术进步已经允许检测和量化导致皮肤老化的各种生理触发因素，并且分子方法已经开始确定这些表型特征的病因。这篇综述将试图总结该领域最近的工作，并对下一波研究提供一些推测。