Time-restricted feeding (TRF) regimens have grown in popularity; however, very few studies have examined their weight-loss efficacy. We conducted the first human trial (Clinicaltrials.gov NCT03867773) to compare the effects of two popular forms of TRF (4 and 6 h) on body weight and cardiometabolic risk factors. Adults with obesity were randomized to 4-h TRF (eating only between 3 and 7 p.m.), 6-h TRF (eating only between 1 and 7 p.m.), or a control group (no meal timing restrictions). After 8 weeks, 4- and 6-h TRF produced comparable reductions in body weight (∼3%), insulin resistance, and oxidative stress, versus controls. Energy intake was reduced by ∼550 kcal/day in both TRF groups, without calorie counting. These findings suggest that 4- and 6-h TRF induce mild reductions in body weight over 8 weeks and show promise as interventions for weight loss. These diets may also improve some aspects of cardiometabolic health.

限时喂养 (TRF) 方案越来越受欢迎。然而，很少有研究检查它们的减肥效果。我们进行了第一次人体试验 (Clinicaltrials.gov NCT03867773)，以比较两种流行的 TRF 形式（4 小时和 6 小时）对体重和心脏代谢危险因素的影响。肥胖的成年人被随机分配到 4 小时 TRF（仅在下午 3 点至 7 点之间进食）、6 小时 TRF（仅在下午 1 点至 7 点之间进食）或对照组（没有用餐时间限制）。8 周后，与对照组相比，4 小时和 6 小时 TRF 在体重（~3%）、胰岛素抵抗和氧化应激方面产生了相当的降低。两个 TRF 组的能量摄入均减少了约 550 kcal/天，没有计算卡路里。这些研究结果表明，4 小时和 6 小时 TRF 可在 8 周内引起体重轻微减轻，并有望作为减肥干预措施。这些饮食还可以改善心脏代谢健康的某些方面。