Introduction

Studies have shown that high levels of the fibrinogen (FIB) are related to anxiety and depression. However, the relationship between FIB and post-stroke emotional impairment (PSEI) remains unclear, which includes post-stroke anxiety (PSA) and post-stroke depression (PSD).

Methods

A total of 555 patients with acute ischemic stroke (AIS) were enrolled in this study. Ultimately, 443 patients completed 1‐month follow‐up. Blood samples were collected at hospital admission. Clinical depression and anxiety were evaluated 1 month after stroke.

Results

High levels of FIB were observed in patients with PSEI compared with the non‐EI group (p = 0.003). Levels of FIB were divided into three tertiles, and the prevalence of PSEI was significantly higher in the third FIB tertile (p = 0.016). After adjusting potential confounders, the third FIB tertile was independently associated with the prevalence of PSEI (OR = 1.785, 95%CI = 1.049–3.039, p = 0.033), taking the first tertile as a reference. In this model, prothrombin time (PT) was also independently associated with the prevalence of PSEI (OR = 1.602, 95%CI = 1.181–2.173, p = 0.002).

Conclusion

High levels of plasma FIB and PT are associated with the prevalence of PSEI.

中文翻译：

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高水平的血浆纤维蛋白原和凝血酶原时间与中风后情绪障碍有关。

介绍

研究表明，高水平的纤维蛋白原 (FIB) 与焦虑和抑郁有关。然而，FIB 与卒中后情绪障碍（PSEI）之间的关系尚不清楚，包括卒中后焦虑（PSA）和卒中后抑郁（PSD）。

方法

本研究共招募了 555 名急性缺血性卒中 (AIS) 患者。最终，443 名患者完成了 1 个月的随访。入院时采集血样。在中风后 1 个月评估临床抑郁和焦虑。

结果

与非 EI 组相比，PSEI 患者的 FIB 水平较高（p = 0.003）。FIB 水平分为三个三分位数，PSEI 的患病率在第三个 FIB 三分位数中显着更高（p  = 0.016）。调整潜在混杂因素后，第三个 FIB 三分位数与 PSEI 的患病率独立相关（OR = 1.785，95%CI = 1.049–3.039，p  = 0.033），以第一个三分位数为参考。在该模型中，凝血酶原时间 (PT) 也与 PSEI 的患病率独立相关（OR = 1.602，95%CI = 1.181–2.173，p  = 0.002）。

结论

高水平的血浆 FIB 和 PT 与 PSEI 的流行有关。