当前位置：
X-MOL 学术
›
RSC Med. Chem.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Fenretinide binding to the lysosomal protein saposin D alters ceramide solubilization and hydrolysis
RSC Medicinal Chemistry ( IF 4.1 ) Pub Date : 2020-07-14 , DOI: 10.1039/d0md00182a Brandon T Milliken 1 , Lindy Melegari 1 , Gideon L Smith 2 , Kris Grohn 3 , Aaron J Wolfe 3, 4 , Kelsey Moody 3, 4 , Fadi Bou-Abdallah 2 , Robert P Doyle 1, 5
RSC Medicinal Chemistry ( IF 4.1 ) Pub Date : 2020-07-14 , DOI: 10.1039/d0md00182a Brandon T Milliken 1 , Lindy Melegari 1 , Gideon L Smith 2 , Kris Grohn 3 , Aaron J Wolfe 3, 4 , Kelsey Moody 3, 4 , Fadi Bou-Abdallah 2 , Robert P Doyle 1, 5
Affiliation
|
Fenretinide is a synthetic retinoid pharmaceutical linked to ceramide build-up in vivo. Saposin D is an intralysosomal protein necessary for ceramide binding/degradation. We show, via electronic absorption spectroscopy, fluorescence spectroscopy, and ceramide hydrolysis assays, that fenretinide is bound by saposin D {Ka = (1.45 ± 0.49) × 105 M−1}, and affects ceramide solubilization/degradation.
中文翻译：
芬维 A 胺与溶酶体蛋白 saposin D 结合可改变神经酰胺溶解和水解
芬维A胺是一种合成类维生素A药物，与体内神经酰胺的积累有关。 Saposin D 是神经酰胺结合/降解所必需的溶酶体内蛋白质。我们通过电子吸收光谱、荧光光谱和神经酰胺水解测定表明，芬维A胺与saposin D { Ka = (1.45 ± 0.49) × 10 5 M -1 } 结合，并影响神经酰胺溶解/降解。
更新日期：2020-07-14
中文翻译：
芬维 A 胺与溶酶体蛋白 saposin D 结合可改变神经酰胺溶解和水解
芬维A胺是一种合成类维生素A药物，与体内神经酰胺的积累有关。 Saposin D 是神经酰胺结合/降解所必需的溶酶体内蛋白质。我们通过电子吸收光谱、荧光光谱和神经酰胺水解测定表明，芬维A胺与saposin D { Ka = (1.45 ± 0.49) × 10 5 M -1 } 结合，并影响神经酰胺溶解/降解。
京公网安备 11010802027423号