Anterior cervical discectomy and fusion (ACDF) is an alternative to conservative therapy in the treatment of cervical spondylopathy. This study evaluated the clinical outcome of ACDF with BMP-2-adsorbed β-tricalcium phosphate granules. Thirty-two patients with cervical spondylopathy received treatment of ACDF with BMP-2-adsorbed β-tricalcium phosphate granules. The clinical outcomes were evaluated with the Japanese Orthopedic Association (JOA) scores and Neck Disability Index (NDI). Meanwhile, the cervical curvature and intervertebral heights were obtained through lateral cervical X-ray films pre- and postoperatively at each interval, and the precision of cervical fusion was assessed by three-dimensional computed tomography scan. The follow-up averaged 15.2 months (range 13–18). Average JOA scores significantly increased from a preoperative point (7.4 ± 1.2) to each interval after surgery (P < 0.05). NDI decreased from preoperative point (43.1 ± 9.0) to each interval after surgery (P < 0.05). The angles of cervical curvature and intervertebral heights were improved postoperatively and kept throughout the follow-up period. CT scan demonstrated a fusion rate of 82.9% at 6 months postoperatively and was improved to 100% at 12 months postoperatively. In all cases, no complications appeared and reported due to any lapse in surgical procedure skills throughout the follow-up period. Our preliminary findings suggest that BMP-2-adsorbed β-tricalcium phosphate granules will be an effective alternative to autogenous bone grafting for cervical fusion in treating cervical spondylopathy. Our surgical procedure usingβ-tricalcium phosphate granules could improve neurological function, recover intervertebral height and cervical curvature, and could be potentially exploitable in the clinical setting.

中文翻译：

---

颈椎前路椎间盘切除术并与重组人骨形态发生蛋白-2-吸附的β-磷酸三钙颗粒融合：初步报告。

颈椎前路椎间盘切除术和融合术（ACDF）是保守治疗颈椎病的一种替代方法。这项研究评估了BDF-2吸附的β-磷酸三钙颗粒对ACDF的临床疗效。32例颈椎病患者接受了BMP-2吸附的β-磷酸三钙磷酸钙颗粒治疗ACDF。临床结果通过日本骨科协会（JOA）评分和颈部残疾指数（NDI）进行评估。同时，在每个间隔期前后通过侧位X线片获取颈椎曲度和椎间高度，并通过三维计算机断层扫描技术评估颈椎融合的准确性。平均随访15.2个月（范围13-18）。从手术前（7.4±1.2）到手术后每个间隔，平均JOA评分显着提高（P <0.05）。NDI从术前（43.1±9.0）降低到术后每个间隔（P <0.05）。术后宫颈曲度角度和椎间高度的角度得到改善，并在整个随访期间保持不变。CT扫描显示术后6个月的融合率为82.9％，术后12个月的融合率提高至100％。在所有情况下，由于在整个随访期间外科手术技能的任何失误，均未出现并未报告并发症。我们的初步发现表明，BMP-2-吸附的β-磷酸三钙颗粒将成为自体骨移植治疗颈椎病的有效替代方法。