Porous titanium scaffolds can provide sufficient mechanical support and bone growth space for large segmental bone defect repair. However, they fail to restore the physiological environment of bone tissue. Barium titanate (BaTiO₃) is considered a smart material that can produce an electric field in response to dynamic force. Low-intensity pulsed ultrasound stimulation (LIPUS), as a kind of micromechanical wave, can not only promote bone repair but also induce BaTiO₃ to generate an electric field. In our studies, BaTiO₃ was coated on porous Ti6Al4V and LIPUS was externally applied to observe the influence of the piezoelectric effect on the repair of large bone defects in vitro and in vivo. The results show that the piezoelectric effect can effectively promote the osteogenic differentiation of bone marrow stromal cells (BMSCs) in vitro as well as bone formation and growth into implants in vivo. This study provides an optional alternative to the conventional porous Ti6Al4V scaffold with enhanced osteogenesis and osseointegration for the repair of large bone defects.

多孔钛支架可为大节段性骨缺损修复提供足够的机械支撑和骨生长空间。然而，它们不能恢复骨组织的生理环境。钛酸钡 (BaTiO ₃ ) 被认为是一种智能材料，可以响应动态力产生电场。低强度脉冲超声刺激（LIPUS）作为一种微机械波，不仅可以促进骨修复，还可以诱导BaTiO ₃产生电场。在我们的研究中，BaTiO ₃涂覆在多孔Ti6Al4V上，外用LIPUS，观察压电效应对体内外大骨缺损修复的影响。结果表明，压电效应可有效促进体外骨髓基质细胞（BMSCs）的成骨分化以及体内骨形成和植入物的生长。这项研究为传统多孔 Ti6Al4V 支架提供了一种可选的替代方案，具有增强的成骨和骨整合，用于修复大骨缺损。