Background. The relative rarity of ischemic compared with traumatic spinal cord injury (SCI) has limited a comparison of the outcomes of these conditions. Objective. To investigate the neurological and functional recovery of ischemic compared with traumatic acute SCI. Methods. Data were derived from the European Multicenter Study Spinal Cord Injury database. Patients with ischemic (iSCI) or traumatic SCI (tSCI), aged 18 years or older were evaluated at different time points from incidence: at about 1 month, 3 months, and 6 months. The neurological status was assessed at each time point by the International Standards for Neurological Classification of Spinal Cord Injury and the functional status by the Spinal Cord Independence Measure. Walking ability was evaluated by Walking Index for Spinal Cord Injury, 10-Meter Walk Test, and 6-Minute Walk Test. Because of the imbalances of the 2 groups in respect to size and lesion severity, a matching procedure according to age, neurological level, and severity of injury was performed. Outcomes evaluation was performed by means of a 2-way repeated-measures ANOVA. Results. The matching procedure resulted in 191 pairs. Both groups significantly improved from about 15 days after the lesion to 6 months. No differences were found in the course of neurological and functional recovery of iSCI compared with tSCI. Conclusions. This analysis from a representative cohort of participants revealed that from 15 days following the cord damage onward, the outcomes after iSCI and tSCI are comparable. This finding supports the potential enrolment of patients with acute iSCI into clinical trials from that point in time after the event and an evaluation up to 6 months afterward.

中文翻译：

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急性外伤性和缺血性脊髓损伤具有相似的恢复过程

背景。与外伤性脊髓损伤 (SCI) 相比，缺血的相对罕见性限制了对这些情况的结果的比较。目标。与外伤性急性 SCI 相比，研究缺血性的神经和功能恢复情况。方法。数据来自欧洲多中心研究脊髓损伤数据库。年龄在 18 岁或以上的缺血性 (iSCI) 或创伤性 SCI (tSCI) 患者在不同的时间点接受评估：大约 1 个月、3 个月和 6 个月。通过脊髓损伤神经学分类国际标准在每个时间点评估神经系统状态，通过脊髓独立性测量评估功能状态。步行能力通过脊髓损伤步行指数、10米步行测试和6分钟步行测试进行评估。由于两组在大小和病变严重程度方面的不平衡，根据年龄、神经系统水平和损伤严重程度进行了匹配程序。通过 2 向重复测量方差分析进行结果评估。结果。匹配程序产生了 191 对。两组从病变后约 15 天到 6 个月都有显着改善。与 tSCI 相比，iSCI 的神经和功能恢复过程中没有发现差异。结论。来自一组代表性参与者的分析表明，从脊髓损伤后 15 天开始，iSCI 和 tSCI 后的结果具有可比性。