BACKGROUND Longitudinal evolution of cortical thickness (CTh) in different MS phenotypes has been rarely studied. AIM To investigate the regional pattern and 1-year progression of cortical thinning in relapsing-remitting (RR) and progressive (P) MS. METHODS 3T high-resolution T1-weighted magnetic resonance imaging (MRI) was obtained from 86 patients (75 RRMS, 11 PMS) and 34 healthy controls (HC) at three European sites at baseline and 1-year follow-up. Using FreeSurfer, baseline CTh between-group differences, longitudinal CTh changes and their correlations with clinical and MRI variables were assessed. RESULTS Baseline frontal, parietal and sensorimotor atrophy was found in MS versus HC. Such pattern was driven by RRMS, while PMS showed additional parietal, insular and sensorimotor cortical atrophy versus RRMS. At 1-year versus baseline, additional frontal and temporal cortical thinning was detected in RRMS patients, while a widespread CTh reduction was found in PMS patients (significant at time-by-group interaction vs RRMS). In MS, baseline fronto-parietal atrophy correlated with more severe disability and higher lesion volume. Baseline inferior parietal CTh decrease and 1-year temporal cortical thinning correlated with more severe disability. CONCLUSION Parieto-temporal baseline CTh abnormalities and thinning pattern over time characterized the main MS clinical phenotypes and were associated with 1-year disability worsening.

中文翻译：

---

纵向皮质变薄进展因多发性硬化症表型而异，并且具有临床相关性：一项多中心研究

背景 很少研究不同 MS 表型中皮质厚度 (CTh) 的纵向演变。目的 研究复发缓解型 (RR) 和进展型 (P) MS 皮质变薄的区域模式和 1 年进展。方法 3T 高分辨率 T1 加权磁共振成像 (MRI) 从 86 名患者 (75 RRMS, 11 PMS) 和 34 名健康对照 (HC) 在三个欧洲站点获得基线和 1 年随访。使用 FreeSurfer，评估基线 CTh 组间差异、纵向 CTh 变化及其与临床和 MRI 变量的相关性。结果 在 MS 与 HC 中发现基线额叶、顶叶和感觉运动萎缩。这种模式是由 RRMS 驱动的，而 PMS 与 RRMS 相比显示出额外的顶叶、岛叶和感觉运动皮层萎缩。在 1 年与基线相比，在 RRMS 患者中检测到额外的额叶和颞叶皮质变薄，而在 PMS 患者中发现广泛的 CTh 减少（在按时间分组的交互中与 RRMS 相比显着）。在 MS 中，基线额顶叶萎缩与更严重的残疾和更大的病灶体积相关。基线下顶叶 CTh 降低和 1 年颞叶皮质变薄与更严重的残疾相关。结论 顶颞基线 CTh 异常和随时间变薄的模式是主要 MS 临床表型的特征，并且与 1 年残疾恶化相关。基线额顶叶萎缩与更严重的残疾和更大的病灶体积相关。基线下顶叶 CTh 降低和 1 年颞叶皮质变薄与更严重的残疾相关。结论 顶颞基线 CTh 异常和随时间变薄的模式是主要 MS 临床表型的特征，并且与 1 年残疾恶化相关。基线额顶叶萎缩与更严重的残疾和更大的病灶体积相关。基线下顶叶 CTh 降低和 1 年颞叶皮质变薄与更严重的残疾相关。结论 顶颞基线 CTh 异常和随时间变薄的模式是主要 MS 临床表型的特征，并且与 1 年残疾恶化相关。