A significant health risk exists within a section of health workers that are exposed to anaesthetic gas and vapours, found in the atmosphere of treatment or operating rooms. These compounds are classified as waste anaesthetic gases (WAG). The present study aimed at identifying alterations in hepatic and haematological parameters occurring as a result of chronic exposure to WAG potentially affecting the health of team members working in hospitals. Therefore, operating room operatives, vulnerable to long-standing WAG exposure, were recruited for this study. Sevoflurane anaesthesia metabolites (inorganic fluoride and hexafluoroisopropanol (HFIP)), haematological indices and liver toxicity markers (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, gamma-glutamyl transferase and osteopontin) were measured. The collected results showed increased plasma inorganic fluoride, HFIP and liver toxicity markers, as well as disturbances in haematological parameters. In conclusion, exposure to halogenated inhalational anaesthetics, in general, and Sevoflurane, in particular, induces alterations in hepatic markers and haematological indices.

在治疗室或手术室的环境中，暴露于麻醉气体和蒸气中的一部分医务人员内部存在重大健康风险。这些化合物被分类为废麻醉气体（WAG）。本研究旨在确定由于长期暴露于WAG而引起的肝脏和血液学参数的变化，这些变化可能会影响在医院工作的团队成员的健康。因此，招募了容易长期暴露于WAG中的手术室操作员进行此项研究。测量了七氟醚的麻醉代谢物（无机氟化物和六氟异丙醇（HFIP）），血液学指标和肝脏毒性标志物（丙氨酸氨基转移酶，天冬氨酸氨基转移酶，碱性磷酸酶，γ-谷氨酰转移酶和骨桥蛋白）。收集的结果显示血浆无机氟化物，HFIP和肝毒性指标增加，以及血液学参数受到干扰。总之，一般而言，暴露于卤化吸入麻醉药中，尤其是七氟醚，会引起肝标志物和血液学指标的改变。