A Highly Selective Fluorescent Probe for Hg2+ Based on a 1,8-Naphthalimide Derivative.,ACS Omega

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A Highly Selective Fluorescent Probe for Hg2+ Based on a 1,8-Naphthalimide Derivative.
ACS Omega ( IF 3.7 ) Pub Date : 2020-07-14 , DOI: 10.1021/acsomega.0c01790
Meiju Tian ₁ , Chunyan Wang ₁ , Qiujuan Ma _{1,

2} , Yu Bai ₁ , Jingguo Sun ₁ , Chunfeng Ding ₃

Affiliation

Hg²⁺ has a significant hazardous impact on the environment and ecosystem. There is a great demand for new methods with high selectivity and sensitivity to determine mercury in life systems and environments. In this paper, a novel turn-on Hg²⁺ fluorescent probe has been reported with a naphthalimide group. The Hg²⁺ fluorescent probe was designed by the inspiration of the well-known specific Hg²⁺-triggered thioacetal deprotection reaction. A 1,2-dithioalkyl group was chosen as the specific recognition site of Hg²⁺. The probe showed weak fluorescence without Hg²⁺, and the color of the solution was light yellow. In the presence of Hg²⁺, the probe reacted specifically with the mercury ion to produce an aldehyde and emitted strong fluorescence, and the color of the solution also turned light green, thus realizing the monitoring of the mercury ion. The Hg²⁺ fluorescent probe showed outstanding sensitivity and selectivity toward Hg²⁺. Furthermore, the Hg²⁺ fluorescent probe could work in a wide pH range. The linear relationship between the fluorescence intensity at 510 nm and the concentration of Hg²⁺ was obtained in a range of Hg²⁺ concentration from 2.5 × 10^–7 to 1.0 × 10^–5 M. The detection limit was found to be 4.0 × 10^–8 M for Hg²⁺. Furthermore, with little cell toxicity, the probe was successfully applied to the confocal image of Hg²⁺ in PC-12 cells.

中文翻译：

基于 1,8-萘二甲酰亚胺衍生物的 Hg2+ 高选择性荧光探针。

Hg ²⁺对环境和生态系统具有显着的有害影响。人们非常需要具有高选择性和灵敏度的新方法来测定生命系统和环境中的汞。在本文中，报道了一种带有萘酰亚胺基团的新型开启Hg ²⁺荧光探针。 Hg ²⁺荧光探针的设计受到众所周知的特异性Hg ²⁺触发的硫缩醛脱保护反应的启发。选择1,2-二硫代烷基作为Hg ²⁺的特异性识别位点。不含Hg ²⁺时探针发出弱荧光，溶液颜色呈浅黄色。在Hg ²⁺存在下，探针与汞离子发生特异性反应，生成醛并发出强烈的荧光，溶液的颜色也变成浅绿色，从而实现了对汞离子的监测。 Hg ²⁺荧光探针对Hg ²⁺显示出出色的灵敏度和选择性。此外，Hg ²⁺荧光探针可以在较宽的pH范围内工作。 Hg ²⁺浓度在2.5 × 10 ^–7至1.0 × 10 ^–5 M范围内，510 nm处荧光强度与Hg ²⁺浓度呈线性关系。检出限为4.0 × Hg ²⁺为 10 ^–8 M。此外，该探针的细胞毒性很小，成功应用于PC-12细胞中Hg ²⁺的共聚焦图像。

更新日期：2020-07-28

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