Poly(vinylpyrrolidone) (PVP-K90) is widely used to manage dry eye syndrome (DES). The marketed eye drop solutions (high dose) need frequent instillation, affecting the routine lifestyle of patients. PVP-K90-laden contact lenses can be used to overcome the limitations of eye drop solutions (low bioavailability and frequent instillation). However, the conventional methods of PVP-K90 loading show poor loading capacity and short duration of effect. In the present study, we have developed PVP-K90-coated contact lenses via a short curing approach to increase the PVP-K90 loading capacity with a sustained release profile to manage dry eye syndrome. PVP-K90 was loaded by a soaking method (SM-PVP), direct loading (during fabrication, DL-PVP), a combination of soaking and direct loading (DL-SM-PVP), and a novel coating process (SM-PVP-C and DL-SM-PVP-C). The swelling studies suggested improvement in the water uptake (hydration) property of the contact lenses due to the presence of PVP-K90. The optical transparency was within an acceptable range. The in vitro release of PVP-K90 was in the following order: PVP-coated contact lens (168 h) > DL-SM-PVP (168 h) > DL-PVP (96 h) > SM-PVP (72–96 h). PVP-coated contact lenses showed a high burst effect (lubricating effect) and sustained release (3161–448 ng/h between 24 and 168 h) due to high PVP loading/coating in comparison to the uncoated respective contact lenses (964–113 ng/h between 24 and 96 h). In animal studies, the PVP-K90-coated contact lens showed higher tear volume in comparison to the respective uncoated contact lenses and an eye drop solution. This study demonstrates a novel approach of coating a high amount of PVP-K90 on contact lenses for sustained release to manage several ocular diseases like dry eye syndrome, conjunctivitis, and other ocular injuries.

中文翻译：

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新型的聚（乙烯基吡咯烷酮）涂层有机硅隐形眼镜，可在镜片配戴期间提高眼泪体积：体内和体外研究。

聚乙烯吡咯烷酮（PVP-K90）被广泛用于治疗干眼症（DES）。市售的滴眼液（高剂量）需要经常滴注，影响患者的常规生活方式。载有PVP-K90的隐形眼镜可用于克服滴眼液的局限性（生物利用度低和频繁滴注）。但是，传统的PVP-K90装载方法显示出较差的装载能力且作用时间短。在本研究中，我们通过短时间固化方法开发了涂有PVP-K90的隐形眼镜，以增加PVP-K90的负载能力，并具有缓释曲线以控制干眼症。通过浸泡方法（SM-PVP），直接加载（在制造过程中，DL-PVP），浸泡和直接加载的组合（DL-SM-PVP）以及新颖的涂覆工艺（SM-PVP）加载PVP-K90 -C和DL-SM-PVP-C）。溶胀研究表明，由于存在PVP-K90，隐形眼镜的吸水（水合作用）性能得到改善。光学透明性在可接受的范围内。PVP-K90的体外释放顺序如下：涂有PVP的隐形眼镜（168 h）> DL-SM-PVP（168 h）> DL-PVP（96 h）> SM-PVP（72–96 h ）。与未镀膜的隐形眼镜（964-113 ng）相比，PVP镀膜的隐形眼镜具有较高的破裂效果（润滑效果）和持续释放（在24至168 h之间为3161-448 ng / h），这是由于PVP的负载/涂层量高。 / h在24至96小时之间）。在动物研究中，与未涂覆的隐形眼镜和滴眼液相比，涂覆PVP-K90的隐形眼镜显示出更高的泪液体积。