STUDY OBJECTIVES To investigate the dose-dependent impact of moderate alcohol intake on sleep-related cardiovascular (CV) function, in adult men and women. METHODS Twenty-six healthy adults (30-60y; 11 women) underwent three nights of laboratory polysomnographic (PSG) recordings in which different doses of alcohol (low: 1 standard drink for women and 2 drinks for men; high: 3 standard drinks for women and 4 drinks for men; placebo: no-alcohol) were administered in counterbalanced order before bedtime. These led to bedtime average breath alcohol levels of up to 0.02% for the low doses and around 0.05% for the high doses. Autonomic and CV function were evaluated using electrocardiography, impedance cardiography, and beat-to-beat blood pressure monitoring. RESULTS Pre-sleep alcohol ingestion resulted in an overall increase in nocturnal heart rate (HR), suppressed total and high-frequency (vagal) HR variability, reduced baroreflex sensitivity, and increased sympathetic activity, with effects pronounced after high-dose alcohol ingestion (p's<0.05); these changes followed different dose- and measure-dependent nocturnal patterns in men and women. Systolic blood pressure showed greater increases during the morning hours of the high-alcohol dose night compared to the low-alcohol dose night and placebo, in women only (p's<0.05). CONCLUSIONS Acute evening alcohol consumption, even at moderate doses, has marked dose- and time-dependent effects on sleep CV regulation in adult men and women. Further studies are needed to evaluate the potential CV risk of repeated alcohol-related alterations in night-time CV restoration in healthy individuals and in those at high risk for CV diseases, considering sex and alcohol dose and time effects.

中文翻译：

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晚上饮酒对成年男性和女性夜间自主神经和心血管功能的影响：剂量反应实验室调查

研究目的 调查成年男性和女性适度饮酒对睡眠相关心血管 (CV) 功能的剂量依赖性影响。方法 26 名健康成年人（30-60 岁；11 名女性）接受了三个晚上的实验室多导睡眠图 (PSG) 记录，其中不同剂量的酒精（低：女性 1 个标准饮酒量，男性 2 个标准饮酒量；高：男性 3 个标准饮酒量）睡前按平衡顺序服用女性和男性 4 杯饮料；安慰剂：无酒精）。这些导致低剂量的睡前平均呼吸酒精含量高达 0.02%，高剂量的睡前平均呼吸酒精含量约为 0.05%。使用心电图、阻抗心动图和逐次血压监测评估自主神经和心血管功能。结果 睡前摄入酒精会导致夜间心率 (HR) 总体增加，抑制总心率和高频（迷走神经）心率变异性，降低压力感受反射敏感性，并增加交感神经活动，在摄入高剂量酒精后效果显着。 p<0.05); 这些变化遵循男性和女性不同的剂量和测量依赖性夜间模式。仅在女性中，与低酒精剂量夜间和安慰剂相比，高酒精剂量夜间的早晨收缩压显示出更大的升高（p<0.05）。结论 晚上剧烈饮酒，即使是中等剂量，也会对成年男性和女性的睡眠 CV 调节产生显着的剂量和时间依赖性影响。考虑到性别、酒精剂量和时间的影响，需要进一步的研究来评估健康个体和心血管疾病高风险人群夜间心血管恢复中与酒精相关的反复改变的潜在心血管风险。