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Integrative pharmacological mechanism of vitamin C combined with glycyrrhizic acid against COVID-19: findings of bioinformatics analyses
Briefings in Bioinformatics ( IF 9.5 ) Pub Date : 2020-07-14 , DOI: 10.1093/bib/bbaa141
Rong Li 1 , Ka Wu 1 , Yu Li 1 , Xiao Liang 1 , Keng Po Lai 1 , Jian Chen 1
Affiliation  

Coronavirus disease 2019 (COVID-19) is a fatal and fast-spreading viral infection. To date, the number of COVID-19 patients worldwide has crossed over six million with over three hundred and seventy thousand deaths (according to the data from World Health Organization; updated on 2 June 2020). Although COVID-19 can be rapidly diagnosed, efficient clinical treatment of COVID-19 remains unavailable, resulting in high fatality. Some clinical trials have identified vitamin C (VC) as a potent compound pneumonia management. In addition, glycyrrhizic acid (GA) is clinically as an anti-inflammatory medicine against pneumonia-induced inflammatory stress. We hypothesized that the combination of VC and GA is a potential option for treating COVID-19.

中文翻译:

维生素C联合甘草酸抗COVID-19的综合药理机制:生物信息学分析结果

2019 年冠状病毒病 (COVID-19) 是一种致命且快速传播的病毒感染。迄今为止,全球 COVID-19 患者人数已超过 600 万,死亡人数超过 37 万人(根据世界卫生组织的数据;2020 年 6 月 2 日更新)。尽管可以快速诊断出 COVID-19,但仍无法对 COVID-19 进行有效的临床治疗,导致死亡率很高。一些临床试验已确定维生素 C (VC) 是一种有效的复合肺炎治疗方法。此外,甘草酸(GA)在临床上被用作对抗肺炎引起的炎症应激的抗炎药物。我们假设 VC 和 GA 的组合是治疗 COVID-19 的潜在选择。
更新日期:2020-07-14
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