Despite recent setbacks with p53-activating small molecules including the nutlins, the cancer target keeps drug hunters coming back for more. Could immuno-oncology combinations, stapled peptides and targeted degraders unleash the therapeutic potential of the ‘guardian of the genome’?

中文翻译：

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p53程序启动。

尽管最近p53激活小分子（包括坚果蛋白）遭受挫折，但癌症的目标仍使药物猎人更多。免疫肿瘤学组合，固定肽和靶向降解剂能否释放“基因组守护者”的治疗潜力？