Abstract Cedrus deodara is a cedar plant from the Pinaceae family. Because Cedrus is widely used in health care products, cosmetics, medicine, and insecticides, the essential oils of Cedrus deodara (CDEOs) are gaining increasing levels of attention. However, there have only been a few studies on the anti-inflammatory effects of CDEOs. This study aimed to systematically study the composition and biological effects of CDEOs, in line with this, the study assessed the chemical composition of CDEOs and evaluated their anti-inflammatory mechanisms in mice. Gas chromatography-mass spectrometry (GC-MS) was used to determine and analyze a total of 41 compounds from CDEOs. It was found that the major components of CDEOs are thujopsene (28.23%), α-cedrene (17.01%), and cedrol (15.55%); moreover, our results showed that the active ingredients in CDEOs have anti-inflammatory and antioxidant effects and that the active ingredients in CDEOs can be used as an antioxidant, as an important biological resource in functional food, and as ingredients in cosmetics and pharmaceuticals. Taken together, these CDEOs serve as ideal additives for anti-inflammatory drugs.

中文翻译：

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雪松叶精油通过抑制 COX-2/TNF-α/NF-κB 激活对 TPA 诱导的耳部水肿发挥抗炎作用

摘要 雪松是松科雪松属的一种植物。由于雪松广泛用于保健品、化妆品、医药和杀虫剂，雪松精油 (CDEO) 越来越受到关注。然而，关于CDEOs抗炎作用的研究很少。本研究旨在系统地研究CDEOs的组成和生物学效应，据此，本研究评估了CDEOs的化学成分并评估了其在小鼠体内的抗炎机制。气相色谱-质谱联用 (GC-MS) 用于测定和分析来自 CDEO 的总共 41 种化合物。结果表明，CDEOs的主要成分是thujopsene（28.23%）、α-雪松烯（17.01%）和雪松酚（15.55%）；而且，我们的研究结果表明，CDEOs 中的活性成分具有抗炎和抗氧化作用，CDEOs 中的活性成分可用作抗氧化剂、功能性食品中的重要生物资源以及化妆品和药品中的成分。总之，这些 CDEO 可作为抗炎药物的理想添加剂。