We report hyperpolarized Xe signal advancement by metal-organic framework (MOF) entrapment (Hyper-SAME) in aqueous solution. The ¹²⁹Xe NMR signal is drastically promoted by entrapping the Xe into the pores of MOFs. The chemical shift of entrapped ¹²⁹Xe is clearly distinguishable from that of free ¹²⁹Xe in water, due to the surface and pore environment of MOFs. The influences from the crystal size of MOFs and their concentration in water are studied. A zinc imidazole MOF, zeolitic imidazole framework-8 (ZIF-8), with particle size of 110 nm at a concentration of 100 mg/mL, was used to give an NMR signal with intensity four times that of free ¹²⁹Xe in water. Additionally, Hyper-SAME is compatible with hyperpolarized ¹²⁹Xe chemical exchange saturation transfer. The ¹²⁹Xe NMR signal can be amplified further by combining the two techniques. More importantly, Hyper-SAME provides a way to make detection of hyperpolarized ¹²⁹Xe in aqueous solution convenient and broadens the application area of MOFs.

我们报告了水溶液中金属有机骨架（MOF）包裹（Hyper-SAME）的超极化Xe信号的进展。的¹²⁹ Xe的NMR信号急剧通过将药物包埋氙到的MOF的孔隙促进。由于MOF的表面和孔隙环境，截留的¹²⁹ Xe的化学位移与水中的游离¹²⁹ Xe的化学位移明显不同。研究了MOF的晶体尺寸及其在水中的浓度的影响。咪唑锌MOF，沸石咪唑骨架8（ZIF-8），在100 mg / mL浓度下的粒径为110 nm，用于产生NMR信号，其强度是水中游离¹²⁹ Xe的四倍。此外，Hyper-SAME与超极化¹²⁹兼容氙化学交换饱和转移。的¹²⁹ Xe的NMR信号可进一步通过组合这两种技术进行扩增。更重要的是，Hyper-SAME提供了一种简便的方法来检测水溶液中的超极化¹²⁹ Xe，并拓宽了MOF的应用领域。