Pencils and papers are ubiquitous in our society and have been widely used for writing and drawing, because they are easy to use, low-cost, widely accessible, and disposable. However, their applications in emerging skin-interfaced health monitoring and interventions are still not well explored. Herein, we report a variety of pencil–paper-based on-skin electronic devices, including biophysical (temperature, biopotential) sensors, sweat biochemical (pH, uric acid, glucose) sensors, thermal stimulators, and humidity energy harvesters. Among these devices, pencil-drawn graphite patterns (or combined with other compounds) serve as conductive traces and sensing electrodes, and office-copy papers work as flexible supporting substrates. The enabled devices can perform real-time, continuous, and high-fidelity monitoring of a range of vital biophysical and biochemical signals from human bodies, including skin temperatures, electrocardiograms, electromyograms, alpha, beta, and theta rhythms, instantaneous heart rates, respiratory rates, and sweat pH, uric acid, and glucose, as well as deliver programmed thermal stimulations. Notably, the qualities of recorded signals are comparable to those measured with conventional methods. Moreover, humidity energy harvesters are prepared by creating a gradient distribution of oxygen-containing groups on office-copy papers between pencil-drawn electrodes. One single-unit device (0.87 cm²) can generate a sustained voltage of up to 480 mV for over 2 h from ambient humidity. Furthermore, a self-powered on-skin iontophoretic transdermal drug-delivery system is developed as an on-skin chemical intervention example. In addition, pencil–paper-based antennas, two-dimensional (2D) and three-dimensional (3D) circuits with light-emitting diodes (LEDs) and batteries, reconfigurable assembly and biodegradable electronics (based on water-soluble papers) are explored.

铅笔和纸在我们的社会中无处不在，并且因为它们易于使用，成本低廉，易于使用且易于使用，因此已被广泛用于书写和绘画。然而，它们在新兴的皮肤界面健康监测和干预中的应用仍未得到很好的探索。在此，我们报告了多种基于铅笔纸的皮肤电子设备，包括生物物理（温度，生物电势）传感器，汗液生化（pH，尿酸，葡萄糖）传感器，热刺激器和湿度能量收集器。在这些设备中，铅笔绘制的石墨图案（或与其他化合物结合使用）用作导电迹线和感应电极，而办公室复印纸则用作柔性支撑基板。启用的设备可以执行实时，连续，和高保真监测人体的一系列重要生物物理和生化信号，包括皮肤温度，心电图，肌电图，α，β和θ节律，瞬时心率，呼吸率以及汗液pH，尿酸和葡萄糖，并提供编程的热刺激。值得注意的是，记录信号的质量可与常规方法测得的质量相比。此外，湿度能量收集器是通过在铅笔状电极之间的办公室复印纸上创建含氧基团的梯度分布而制备的。一台单装置（0.87厘米 和葡萄糖，以及提供程序化的热刺激。值得注意的是，记录信号的质量可与常规方法测得的质量相比。此外，湿度能量收集器是通过在铅笔状电极之间的办公室复印纸上创建含氧基团的梯度分布而制备的。一台单装置（0.87厘米 和葡萄糖，以及提供程序化的热刺激。值得注意的是，记录信号的质量可与常规方法测得的质量相比。此外，湿度能量收集器是通过在铅笔状电极之间的办公室复印纸上创建含氧基团的梯度分布而制备的。一台单装置（0.87厘米²）可以在环境湿度下持续2小时以上产生高达480 mV的持续电压。此外，作为皮肤化学干预实例，开发了自供电的皮肤离子电渗透皮药物递送系统。此外，还探索了基于铅笔纸的天线，带有发光二极管（LED）和电池的二维（2D）和三维（3D）电路，可重构的组件和可生物降解的电子产品（基于水溶性纸张） 。