The Pauson–Khand reaction (PKR) is one of the key methods for the construction of cyclopentenone derivatives, which can in turn undergo diverse chemical transformations to yield more complex biologically active molecules. Despite the increasing availability of fluorinated building blocks and methodologies to incorporate fluorine in compounds with biological interest, there have been few significant advances focused on the fluoro-Pauson–Khand reaction, both in the inter- and intramolecular versions. Furthermore, the use of vinyl fluorides as olefinic counterparts had been completely overlooked. In this review, we collect the advances both on the stoichiometric and catalytic intermolecular and intramolecular fluoro-Pauson–Khand reaction, with special attention to the PKR of enynes containing a fluoride moiety.

中文翻译：

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氟化化合物的Pauson-Khand反应。

Pauson-Khand反应（PKR）是构建环戊烯酮衍生物的关键方法之一，而环戊烯酮衍生物又可以经历各种化学转化以产生更复杂的生物活性分子。尽管越来越多的氟化结构单元和方法将氟掺入具有生物学价值的化合物中，但分子间和分子内版本都很少关注氟-鲍森-汉德反应。此外，完全忽略了氟乙烯作为烯烃的对应物。在这篇综述中，我们收集了化学计量的和催化的分子间和分子内氟-Pauson-Khand反应的研究进展，并特别关注了含有氟化物部分的炔烃的PKR。