Bisphenol A (BPA), as a common industrial component, is generally consumed in the synthesis of polymeric materials. To gain a deeper understanding of the detrimental effects of BPA, BPA‐induced microRNA (miRNA) alterations were investigated. A systematic search was performed in the PubMed, SCOPUS and Web of Science databases to evoke relevant published data up to August 10, 2019. We identified altered miRNAs that have been repeated in at least three studies. Moreover, miRNA homology analysis between human and nonhuman species was performed to determine the toxicity signatures of BPA in human exposure. In addition, to reflect the effects of environmental exposure levels of BPA, the study designs were categorized into two groups, including low and high doses according to the previous definitions. In total, 28 studies encountered our criteria and 17 miRNAs were identified that were differentially expressed in at least three independent studies. Upregulating miR‐146a and downregulating miR‐192, miR‐134, miR‐27b and miR‐324 were found in three studies. MiR‐122 and miR‐29a were upregulated in four studies after BPA exposure, and miR‐21 was upregulated in six studies. The results indicate that BPA at low‐level exposures can also alter miRNA expression in response to toxicity. Finally, the miRNA‐related pathways showed that BPA seriously can affect human health through various cell signaling pathways, which were predictable and consistent with existing studies. Overall, our findings suggest that further studies should be conducted to examine the role of miRNA level changes in human BPA exposure.

中文翻译：

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对暴露于双酚 A 的 microRNA 表达研究的系统评价。

双酚 A (BPA) 作为一种常见的工业成分，通常用于聚合材料的合成。为了更深入地了解 BPA 的不利影响，研究了 BPA 诱导的 microRNA (miRNA) 改变。在 PubMed、SCOPUS 和 Web of Science 数据库中进行了系统搜索，以提取截至 2019 年 8 月 10 日的相关已发表数据。我们确定了至少在三项研究中重复的改变的 miRNA。此外，还进行了人类和非人类物种之间的 miRNA 同源性分析，以确定人类暴露中 BPA 的毒性特征。此外，为了反映 BPA 环境暴露水平的影响，研究设计分为两组，根据之前的定义，包括低剂量和高剂量。总共，28 项研究符合我们的标准，并且在至少三项独立研究中鉴定了 17 种差异表达的 miRNA。在三项研究中发现了上调 miR-146a 和下调 miR-192、miR-134、miR-27b 和 miR-324。在 BPA 暴露后，四项研究中 MiR-122 和 miR-29a 上调，六项研究中 miR-21 上调。结果表明，低水平暴露的 BPA 也可以改变 miRNA 表达以响应毒性。最后，miRNA相关通路表明BPA可以通过各种细胞信号通路严重影响人类健康，这与现有研究一致。总的来说，我们的研究结果表明应该进行进一步的研究来检查 miRNA 水平变化在人类 BPA 暴露中的作用.