Inhibin, beta A (INHBA) is a member of the transforming growth factor (TGF‐β) family. The carcinogenic mechanisms of INHBA during the development of colorectal cancer (CRC) remain unclear. In the present study, we further elucidated the role of INHBA in CRC. We analysed the expression of INHBA in CRC and its relationship with patient prognosis using data from public databases. INHBA expression was evaluated in CRC tissues and cell lines using immunohistochemistry and western blotting. After inhibiting the expression of INHBA, the effect of INHBA on the function of CRC cells was evaluated in vitro. We found that INHBA was upregulated in CRC. High INHBA expression is closely related to poor prognosis in patients with CRC. Knockdown of INHBA in vitro can inhibit the proliferation, migration, and invasion of CRC cells. In terms of mechanism, we found that high INHBA expression activates the TGF‐β pathway.

中文翻译：

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抑制素，βA调节转化生长因子-β途径，以促进大肠癌的恶性生物学行为

抑制素βA（INHBA）是转化生长因子（TGF-β）家族的成员。在结直肠癌（CRC）发展过程中，INHBA的致癌机制仍不清楚。在本研究中，我们进一步阐明了INHBA在CRC中的作用。我们使用来自公共数据库的数据分析了INHBA在CRC中的表达及其与患者预后的关系。使用免疫组织化学和蛋白质印迹法评估了CRC组织和细胞系中的INHBA表达。抑制INHBA的表达后，在体外评估INHBA对CRC细胞功能的影响。我们发现，INHBA在CRC中被上调。INHBA高表达与CRC患者的不良预后密切相关。体外抑制INHBA可以抑制CRC细胞的增殖，迁移和侵袭。在机制上，