This work evaluated the formation of transformation products (TPs) during the degradation of diazepam (DZP) by a solar photo-Fenton process. Six TPs were identified, three of them for the first time. After elucidation of the TPs, a new, cheap, fast, and easy method was employed to extract and preconcentrate DZP and its TPs, using dispersive liquid-liquid microextraction (DLLME). The method was optimized using factorial and Doehlert designs, with the best results obtained using acetonitrile as disperser solvent and chloroform as extraction solvent, with volumes of 1000 and 650 µL, respectively. When DZP degradation was performed in ultrapure water, the extraction/preconcentration of DZP and its TPs by DLLME was very similar to the results obtained using a traditional SPE method. However, when hospital wastewater was used as the matrix, more limited extraction efficiency was obtained using DLLME, compared to SPE. Meanwhile, all the TPs extracted by SPE were also extracted by the DLLME technique. Furthermore, DLLME was much less expensive than SPE, besides being faster, easier, and requiring only small amounts of organic solvents. This work reports a new and very important tool for the extraction and preconcentration of TPs formed during degradation using techniques such as advanced oxidation processes (AOPs), since without this step it would not be possible to identify all the TPs formed in some complex wastewater matrices.

这项工作评估了通过太阳光芬顿法降解地西epa（DZP）期间转化产物（TPs）的形成。确定了六个TP，其中三个是首次。在阐明了TP之后，采用了一种分散，液-液微萃取（DLLME）提取，预浓缩DZP及其TP的新方法，该方法便宜，快速，简便。使用阶乘和Doehlert设计对方法进行了优化，使用乙腈作为分散溶剂，氯仿作为萃取溶剂，分别得到1000和650 µL的体积可获得最佳结果。在超纯水中进行DZP降解时，DLLME对DZP及其TP的萃取/预浓缩与使用传统SPE方法获得的结果非常相似。但是，当医院废水用作基质时，与SPE相比，使用DLLME可获得更高的提取效率。同时，通过DLLME技术还提取了SPE提取的所有TP。此外，DLLME比SPE便宜得多，除了更快，更容易且仅需要少量有机溶剂外。这项工作报告了一种新的且非常重要的工具，该工具可使用诸如高级氧化工艺（AOP）之类的技术来提取和预浓缩降解过程中形成的TP，因为如果没有此步骤，将无法识别在某些复杂废水基质中形成的所有TP。 。并且只需要少量的有机溶剂。这项工作报告了一种新的且非常重要的工具，该工具使用诸如高级氧化工艺（AOP）之类的技术来提取和预浓缩降解过程中形成的TP，因为如果没有此步骤，将无法识别在某些复杂废水基质中形成的所有TP。 。并且只需要少量的有机溶剂。这项工作报告了一种新的且非常重要的工具，该工具可使用诸如高级氧化工艺（AOP）之类的技术来提取和预浓缩降解过程中形成的TP，因为如果没有此步骤，将无法识别在某些复杂废水基质中形成的所有TP。 。