ABSTRACT Recent increases in antibiotic resistance and corresponding decreases in the development of new antimicrobial therapies have made new antibiotic discovery a high priority. Traditional medicines have potential for antibiotic discovery, although synergistic combinations consisting of plant extracts and conventional antibiotics may be a more effective approach. The combinations may overcome resistance and repurpose antibiotics that would otherwise be ineffective against resistant bacterial strains. In this study, Terminalia sericea leaves were extracted with solvents of varying polarity and the resultant extracts were investigated for the ability to inhibit bacterial growth using disc diffusion and liquid dilution MIC techniques. The effects of combinations of the extracts and conventional antibiotics (chloramphenicol, ciprofloxacin, erythromycin, gentamycin, penicillin-G or tetracyclin) were also tested using the checkerboard method. Combinations that exhibited synergistic interactions were further examined using isobologram analysis to determine the ideal ratios of extract-antibiotic. Toxicity was evaluated using Artemia nauplii and human dermal fibroblast (HDF) toxicity assays. The methanolic and water T. sericea extracts were good inhibitors of the microbial triggers of several autoimmune diseases, with MIC values substantially

中文翻译：

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Terminalia sericea Burch ex DC 的交互抗菌活性。叶提取物和常规抗生素对抗特定自身免疫性炎症疾病的细菌触发因素

摘要 最近抗生素耐药性的增加和新抗菌疗法开发的相应减少使得新抗生素的发现成为高度优先事项。传统药物具有发现抗生素的潜力，尽管由植物提取物和常规抗生素组成的协同组合可能是一种更有效的方法。这些组合可以克服耐药性并重新利用抗生素，否则这些抗生素对耐药菌株无效。在这项研究中，用不同极性的溶剂提取了榄仁树的叶子，并使用圆盘扩散和液体稀释 MIC 技术研究了所得提取物抑制细菌生长的能力。提取物与常规抗生素（氯霉素、环丙沙星、还使用棋盘法测试了红霉素、庆大霉素、青霉素-G 或四环素）。使用等效线图分析进一步检查表现出协同相互作用的组合，以确定提取物-抗生素的理想比例。使用卤虫无节幼体和人真皮成纤维细胞 (HDF) 毒性试验评估毒性。甲醇和水蚕豆提取物是几种自身免疫性疾病的微生物触发物的良好抑制剂，其 MIC 值显着