Objective

The paper intends to study the protective effects of sulforaphane (SF) on acute alcoholic hepatic injury in mice by intragastric administration of SF, aerobic exercise and the approach of SF integrated with aerobic exercise.

Methodology

60 NIH mice were randomly divided into 6 groups of equal number according to their body weight and were intragastrically administrated with 50% ethanol. The serum and liver indexes of each group of mice were detected, and the liver was stained with oil red O for pathological examination.

Results

Compared with the model group, the serum TG and the ratio of liver to body weight of the model mice that suffered from acute alcoholic hepatic injury could be significantly decreased in the group that practiced aerobic exercise, the group administered with SF, and the group treated with the approach of SF integrated with aerobic exercise (P < 0.05). The contents of TG and MDA in liver could be significantly decreased (P < 0.05) and SOD activity could be significantly increased (P < 0.05) both in the group administered with SF and the group treated with the approach of SF integrated with aerobic exercise. Serum VLDL (P < 0.05) could also be significantly reduced in the group treated with the approach of SF integrated with aerobic exercise.

Conclusion

Both SF and aerobic exercise could alleviate alcohol-induced acute alcoholic hepatic injury in mice possibly thanks to the working mechanism related to antioxidant stress that reduced the harm posed by alcohol on hepatic cells. In addition, the protective effect of SF on acute alcoholic hepatic injury in mice was stronger than that of aerobic exercise, while the approach of SF integrated with aerobic exercise had the strongest protective effect on acute alcoholic hepatic injury in mice.

中文翻译：

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萝卜硫素联合有氧运动对小鼠急性酒精性肝损伤的保护作用

 客观的

本文拟通过灌胃、有氧运动以及萝卜硫素联合有氧运动的方法，研究萝卜硫素（SF）对小鼠急性酒精性肝损伤的保护作用。

 方法

将60只NIH小鼠按体重随机分为6组，均等数量，用50%乙醇灌胃。检测各组小鼠的血清和肝脏指标，并对肝脏进行油红O染色进行病理检查。

 结果

与模型组相比，有氧运动组、SF组和治疗组急性酒精性肝损伤模型小鼠的血清TG和肝脏体重比均明显降低。 SF 结合有氧运动的方法（ P < 0.05）。 SF组和SF联合有氧运动组均能显着降低肝脏TG、MDA含量（ P <0.05），SOD活性显着升高（ P <0.05）。 SF联合有氧运动治疗组血清VLDL也显着降低（ P <0.05）。

 结论

SF和有氧运动均可减轻酒精引起的小鼠急性酒精性肝损伤，这可能是由于与抗氧化应激相关的工作机制减少了酒精对肝细胞造成的伤害。此外，SF对小鼠急性酒精性肝损伤的保护作用强于有氧运动，其中SF联合有氧运动的方式对小鼠急性酒精性肝损伤的保护作用最强。