Paroxysmal dysarthria-ataxia syndrome: Literature review on MRI findings and report of a peculiar case with clinically isolated syndrome coexisting with anti-N-methyl-d-aspartate receptor antibodies,Journal of Neuroimmunology

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Paroxysmal dysarthria-ataxia syndrome: Literature review on MRI findings and report of a peculiar case with clinically isolated syndrome coexisting with anti-N-methyl-d-aspartate receptor antibodies
Journal of Neuroimmunology ( IF 2.9 ) Pub Date : 2020-10-01 , DOI: 10.1016/j.jneuroim.2020.577327
Qingkui Zhang ₁ , Yang Li ₂ , Ruozhuo Liu ₁ , Dehui Huang ₁ , Lei Wu ₃ , Shengyuan Yu ₃

Affiliation

Paroxysmal dysarthria and ataxia (PDA) syndrome constitutes a rare neurological disorder, and is generally reported in cases of multiple sclerosis (MS) involving the midbrain. We present an illustrative case of 32-year-old female who developed clinically isolated syndrome manifested paroxysmal dysarthria, ataxia, ptosis and diplopia, coexisting with anti-N-methyl-d-aspartate receptor antibodies. We review the literature and identify 23 other cases with brain MRI examinations to summarize the lesion locations and clinical characteristics of PDA syndrome, and ultimately provide a new framework for understanding this rare condition. The current case expands the spectrum of symptoms in PDA syndrome, which was including but not limited to dysarthria and ataxia. Caudal paramedian midbrain lesions involving decussation of the superior cerebellar peduncles appear to be critical for PDA syndrome.

中文翻译：

阵发性构音障碍-共济失调综合征：MRI 表现的文献综述和一例临床孤立综合征与抗 N-甲基-d-天冬氨酸受体抗体共存的特殊病例报告

阵发性构音障碍和共济失调 (PDA) 综合征是一种罕见的神经系统疾病，通常在涉及中脑的多发性硬化 (MS) 病例中报告。我们展示了一个 32 岁女性的示例性案例，她出现了临床孤立综合征，表现为阵发性构音障碍、共济失调、上睑下垂和复视，并与抗 N-甲基-d-天冬氨酸受体抗体共存。我们回顾了文献并通过脑部 MRI 检查确定了其他 23 例病例，以总结 PDA 综合征的病变位置和临床特征，并最终为了解这种罕见疾病提供新的框架。本病例扩大了 PDA 综合征的症状范围，包括但不限于构音障碍和共济失调。

更新日期：2020-10-01

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