Immunoglobulin G4-related hypertrophic pachymeningitis with spinal cord compression: A case report,Journal of Neuroimmunology

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Immunoglobulin G4-related hypertrophic pachymeningitis with spinal cord compression: A case report
Journal of Neuroimmunology ( IF 2.9 ) Pub Date : 2020-10-01 , DOI: 10.1016/j.jneuroim.2020.577325
Hong-Xing Li ₁ , Lin Zuo ₁ , Xiao-Xiao Peng ₂ , Qiang Zong ₁ , Kai Zhang ₁ , Yi-Zhe Liu ₁ , Han Wang ₁ , Guang-Liang Han ₁

Affiliation

IgG4-related disease (IgG4-RD) is a recently recognized inflammatory condition that can be found in many organs. However, spinal involvement is rare and has been described only in case reports and series. Here, we report a rare case of spinal IgG4-RD that resulted in hypertrophic pachymeningitis with spinal cord compression. This case expands the phenotypic presentation for the neurological sequelae of IgG4-RD. Our case hints that spinal IgG4-RD may be misdiagnosed, and IgG4-RD in patients should be considered when the patient has a dural mass. Although early surgery, steroids, and/or immunosuppressive therapy may prevent neurological complications, the side effects should receive more attention during treatment.

中文翻译：

免疫球蛋白 G4 相关肥厚性硬脑膜炎伴脊髓压迫：1 例报告

IgG4 相关疾病 (IgG4-RD) 是一种最近发现的炎症性疾病，可在许多器官中发现。然而，脊柱受累很少见，仅在病例报告和系列中有所描述。在这里，我们报告了一个罕见的脊髓 IgG4-RD 病例，该病例导致肥厚性硬脑膜炎伴脊髓受压。该病例扩大了 IgG4-RD 神经系统后遗症的表型表现。我们的病例提示脊髓IgG4-RD可能被误诊，当患者有硬膜肿块时应考虑患者的IgG4-RD。虽然早期手术、类固醇和/或免疫抑制治疗可以预防神经系统并发症，但在治疗过程中应更加注意副作用。

更新日期：2020-10-01

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