Hemorrhagic encephalopathy associated with COVID-19,Journal of Neuroimmunology

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Hemorrhagic encephalopathy associated with COVID-19
Journal of Neuroimmunology ( IF 2.9 ) Pub Date : 2020-09-01 , DOI: 10.1016/j.jneuroim.2020.577326
Jonathan D Krett ₁ , Gordon A E Jewett ₁ , Charissa Elton-Lacasse ₂ , Kevin Fonseca ₃ , Christopher Hahn ₁ , Selena Au ₂ , Marcus W Koch ₄

Affiliation

Abstract The mechanisms for neurological complications of COVID-19, the disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), are not yet well understood. We present a critically ill man with a COVID-19-associated hemorrhagic encephalopathy. SARS-CoV-2 RNA was not detected in cerebrospinal fluid (CSF) or blood. CSF analyses suggested dysregulation of pro-inflammatory cytokine pathways, particularly tumor necrosis factor-α and interleukin-6, consistent with a cytokine release syndrome. The patient gradually recovered with supportive care and neurological rehabilitation. Awareness of this clinical entity may facilitate the identification of patients with a potentially remediable cause of encephalopathy in COVID-19.

中文翻译：

与 COVID-19 相关的出血性脑病

摘要：由严重急性呼吸综合征冠状病毒-2 (SARS-CoV-2) 引起的新冠肺炎 (COVID-19) 神经系统并发症的机制尚不清楚。我们介绍了一名患有 COVID-19 相关出血性脑病的危重患者。在脑脊液 (CSF) 或血液中未检测到 SARS-CoV-2 RNA。脑脊液分析表明促炎细胞因子途径失调，特别是肿瘤坏死因子-α 和白介素-6，与细胞因子释放综合征一致。通过支持治疗和神经康复，患者逐渐康复。对这一临床实体的认识可能有助于识别患有潜在可治愈的 COVID-19 脑病病因的患者。

更新日期：2020-09-01

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