Proteolytic maturation of the pore-forming protein gasdermin D (GSDMD) by inflammasome-activated caspase-1 is crucial for initiating pyroptosis, a lytic form of cell death. In this issue of Immunity, Lui et al. report the X-ray structure of the caspase-1-GSDMD complex, mapping the interaction interfaces that determine recognition and cleavage of GSDMD by inflammatory caspases.

中文翻译：

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致命拥抱的快照：Caspase-1-GSDMD接口。

炎症小体激活的caspase-1对孔形成蛋白gasdermin D（GSDMD）的蛋白水解成熟对于启动细胞凋亡的裂解形式即启动细胞凋亡至关重要。在本期《免疫》中，Lui等人。报告了caspase-1-GSDMD复合物的X射线结构，绘制了确定炎症性胱天蛋白酶对GSDMD识别和裂解的相互作用界面。