A nanoprobe of laser desorption/ionization-time of flight mass spectrometry (LDI-TOF MS) for the determination of small molecules was developed that is based on the composition of Fe-metal organic frameworks (Fe-MOFs) and carboxymethyl cellulose-Na (CMC-Na). This material is a good adsorbent for small molecules via hydrogen bonding and π-interactions; we detected three molecules, dopamine, glyphosate, and pyrene. The detection limits for these compounds are 0.01 mg L−1, 1.50 μg L−1, and 0.01 μg L−1, respectively; the recoveries are 85–117%, 81–127%, and 89–115%, respectively. The relative standard deviations (~ 15%) and coefficients of determination of the calibration plot (~ 0.97) are satisfactory. The applicability of the chip for practical samples is demonstrated by quantifying pyrene in domestic water and polluted lake water; the recoveries are about 90~117% and 85~125% (n = 5), respectively; the RSDs are 9.4% and 13.5%, respectively. Graphical abstract Graphical abstract

中文翻译：

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由铁金属有机骨架和羧甲基纤维素制成的自组装基质用于 MALDI-TOF MS 测定小分子

基于 Fe-金属有机骨架 (Fe-MOFs) 和羧甲基纤维素-Na 的组成，开发了一种用于测定小分子的激光解吸/电离-飞行时间质谱 (LDI-TOF MS) 纳米探针。 CMC-Na)。这种材料是通过氢键和 π 相互作用对小分子的良好吸附剂；我们检测到三种分子，多巴胺、草甘膦和芘。这些化合物的检测限分别为 0.01 mg L-1、1.50 μg L-1 和 0.01 μg L-1；回收率分别为 85-117%、81-127% 和 89-115%。校准图的相对标准偏差 (~ 15%) 和确定系数 (~ 0.97) 令人满意。通过对生活用水和污染湖水中芘进行定量，证明了该芯片对实际样品的适用性；回收率分别约为 90~117% 和 85~125% (n = 5)；RSD 分别为 9.4% 和 13.5%。图形摘要图形摘要