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Current clinical application of sclera and amniotic membrane for ocular tissue bio-replacement.
Cell and Tissue Banking ( IF 1.4 ) Pub Date : 2020-07-13 , DOI: 10.1007/s10561-020-09848-x
Noelia Sabater-Cruz 1 , Marc Figueras-Roca 1 , Andrea González Ventosa 1 , Lydia Padró-Pitarch 2 , Jaume Tort 2 , Ricardo P Casaroli-Marano 1, 3, 4
Affiliation  

To report the current clinical applications and trends of scleral and amniotic membrane use in ophthalmology. Review of annual reports from the Catalan Transplant Organization (OCATT), on scleral patch and amniotic membrane eye indications in Catalonia region (Spain) over a 6-year period from 2013 to 2018. A total of 874 scleral and 1665 amniotic membranes patches were implanted, from January 2013 to December 2018. The most frequent indication over the 6-year period for scleral patch was glaucoma surgery (77.5%), eyelid reconstruction (5.2%) and corneal or scleral ulcer (5%). Regarding amniotic membrane, corneal ulcer (26.9%), conjunctival reconstruction (23.8%) and corneal epithelial defect (22.7%) were the most common indications. During the study period, an increasing trend was found on sclera patches for eyelid reconstruction (p = 0.0032) and amniotic membrane for inflammation management (p = 0.0198). Glaucoma surgery and corneal ulcers have represented the top indications for scleral patch and amniotic membrane use, over the period, respectively. A significant trend has also been found towards eyelid reconstruction using scleral patches and amniotic membrane for anterior segment inflammation management. This evolving scenario in tissue use for ocular surgery has to be taken into consideration, especially regarding eye banks facing current and futures changes in tissue preservation, storage and indications.



中文翻译:

巩膜和羊膜在眼组织生物置换中的临床应用

报告巩膜和羊膜在眼科中的当前临床应用和趋势。回顾加泰罗尼亚移植组织 (OCATT) 的年度报告,关于 2013 年至 2018 年 6 年间加泰罗尼亚地区(西班牙)的巩膜补片和羊膜眼适应症。总共植入了 874 个巩膜和 1665 个羊膜补片2013 年 1 月至 2018 年 12 月。 巩膜贴片 6 年期间最常见的适应症是青光眼手术 (77.5%)、眼睑重建 (5.2%) 和角膜或巩膜溃疡 (5%)。在羊膜方面,角膜溃疡(26.9%)、结膜重建(23.8%)和角膜上皮缺损(22.7%)是最常见的适应症。在研究期间,用于眼睑重建的巩膜贴片有增加的趋势(p  = 0.0032) 和用于炎症管理的羊膜 ( p  = 0.0198)。在此期间,青光眼手术和角膜溃疡分别代表了巩膜补片和羊膜使用的主要适应症。还发现了使用巩膜贴片和羊膜重建眼睑进行眼前节炎症管理的显着趋势。必须考虑眼科手术组织使用的这种不断发展的情况,尤其是眼库面临组织保存、储存和适应症的当前和未来变化。

更新日期:2020-07-14
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