Molecular clusters are valuable building blocks to synthesize hybrid macromolecules, and consequently achieve diverse supramolecular nanostructures via self-assembly. Hybrid macromolecules can be synthesized by covalently linking different molecular clusters and grafting organic molecules onto cluster surface, or through complexation via non-covalent interactions. Through regulation of solution conditions such as solvent polarity, ionic strength, and type of cations, well-defined hybrids exhibit versatile self-assembled behavior determined by their molecular structures including shape, composition, volume fraction, topology, and surface functionality. The incorporation of molecular clusters into polymers can tune the flexibility and architecture of cluster-based copolymers, which fills the phase diagrams with different molecular packings as well as supramolecular nanostructures. The complexation between molecular clusters and other organic molecules provides a promising approach to construct multi-dimensional nanostructures through non-covalent interactions.

分子簇是合成杂化大分子的有价值的组成部分，因此可以通过自组装获得多种超分子纳米结构。杂化大分子可以通过共价连接不同的分子簇并将有机分子接枝到簇表面上或通过非共价相互作用。通过调节溶液条件（例如溶剂极性，离子强度和阳离子类型），定义明确的杂化剂表现出多种自组装行为，这些行为是由其分子结构（包括形状，组成，体积分数，拓扑结构和表面功能性）决定的。将分子簇结合到聚合物中可以调节基于簇的共聚物的柔韧性和结构，这填充了具有不同分子堆积以及超分子纳米结构的相图。分子簇和其他有机分子之间的络合提供了一种通过非共价相互作用构建多维纳米结构的有前途的方法。