Many patients suffering from exercise-induced asthma (EIA) have normal lung function at rest and show symptoms and a decline in FEV1 when they do sports or during exercise-challenge. It has been described that long-chain polyunsaturated fatty acids (LCPUFA) could exert a protective effect on EIA. In this study the protective effect of supplementation with a special combination of n-3 and n-6 LCPUFA (sc-LCPUFA) (total 1.19 g/ day) were investigated in an EIA cold air provocation model. Primary outcome measure: Decrease in FEV1 after exercise challenge and secondary outcome measure: anti-inflammatory effects monitored by exhaled NO (eNO) before and after sc-LCPUFA supplementation versus placebo. Ninety-nine patients with exercise-induced symptoms aged 10 to 45 were screened by a standardized exercise challenge in a cold air chamber at 4 °C. Seventy-three patients fulfilled the inclusion criteria of a FEV1 decrease > 15% and were treated double-blind placebo-controlled for 4 weeks either with sc-LCPUFA or placebo. Thirty-two patients in each group completed the study. Mean FEV1 decrease after cold air exercise challenge and eNO were unchanged after 4 weeks sc-LCPUFA supplementation. Supplementation with sc-LCPUFA at a dose of 1.19 g/d did not have any broncho-protective and anti-inflammatory effects on EIA. Clinical trial registration number: NCT02410096. Registered 7 February 2015 at Clinicaltrial.gov

中文翻译：

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含有n-3和n-6长链多不饱和脂肪酸的特殊组合的机油补充剂不能保护运动诱发的哮喘：一项双盲安慰剂对照试验。

许多患有运动诱发性哮喘（EIA）的患者休息时肺功能正常，运动或运动时表现出症状，FEV1下降。据描述，长链多不饱和脂肪酸（LCPUFA）可以对EIA发挥保护作用。在这项研究中，在EIA冷空气激发模型中研究了以n-3和n-6 LCPUFA（sc-LCPUFA）的特殊组合（总量为1.19 g /天）补充的保护作用。主要结果指标：运动激发后FEV1减少；次要结果指标：sc-LCPUFA与安慰剂相比，在补充sc-LCPUFA前后通过呼出NO（eNO）监测抗炎作用。在4°C的冷空气室中通过标准化运动挑战筛查了9位10-45岁运动诱发症状的患者。73名患者符合FEV1降低> 15％的入选标准，并接受双盲安慰剂对照治疗，使用sc-LCPUFA或安慰剂治疗4周。每组有32名患者完成了研究。补充sc-LCPUFA 4周后，冷空气运动后平均FEV1下降，eNO保持不变。以1.19 g / d的剂量补充sc-LCPUFA对EIA没有任何支气管保护和抗炎作用。临床试验注册号：NCT02410096。2015年2月7日注册在Clinicaltrial.gov 补充sc-LCPUFA 4周后，冷空气运动后平均FEV1下降，eNO保持不变。以1.19 g / d的剂量补充sc-LCPUFA对EIA没有任何支气管保护和抗炎作用。临床试验注册号：NCT02410096。2015年2月7日注册在Clinicaltrial.gov 补充sc-LCPUFA 4周后，冷空气运动后平均FEV1下降，eNO保持不变。以1.19 g / d的剂量补充sc-LCPUFA对EIA没有任何支气管保护和抗炎作用。临床试验注册号：NCT02410096。2015年2月7日注册在Clinicaltrial.gov