A new cadinane-type sesquiterpene named cornifronone is isolated from the body surface of a mason bee (Osmia cornifrons)–derived Streptomyces sp. OC1611-8A. Its structure is identified by high-resolution electrospray ionization mass spectrometry data and nuclear magnetic resonance spectroscopic analysis. The absolute configuration of cornifronone was determined by electronic circular dichroism spectra calculations. Cornifronone inhibits hexokinase activity with a mean IC50 of 124.3 μM.

中文翻译：

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Cornifronone：来自梅森蜜蜂（Osmiacornifrons）的一种cadinane型倍半萜烯-衍生的链霉菌属

从梅森蜜蜂（Osmiacornifrons）衍生的链霉菌属物种的体表分离出一种名为cornifronone的新型cadinane型倍半萜烯。OC1611-8A。其结构通过高分辨率电喷雾电离质谱数据和核磁共振光谱分析进行鉴定。可尼酮的绝对构型通过电子圆二色光谱计算确定。Cornifronone 抑制己糖激酶活性，平均 IC50 为 124.3 μM。