Natural Product Communications ( IF 1.5 ) Pub Date : 2020-05-19 , DOI: 10.1177/1934578x20926729 Amira S. Wanas 1, 2 , Mohamed M. Radwan 1 , Suman Chandra 1 , Hemant Lata 1 , Zlatko Mehmedic 1 , Abbas Ali 1 , KHC Baser 3 , Betul Demirci 4 , Mahmoud A. ElSohly 1, 5
The volatile oils of fresh and air-dried buds of 3 different varieties of Cannabis, namely, high cannabidiol (CBD) chemotype, intermediate CBD/tetrahydrocannabinol (THC) chemotype, and high THC chemotype were prepared by hydrodistillation. Gas chromatography analysis of the volatile oils resulted in the identification of 71 compounds, of which 33 were monoterpenes and 38 were sesquiterpenes. The volatile oil obtained from the THC chemotype showed an increase in the ratio of the sesquiterpenes to monoterpenes content. The content of terpinolene was dramatically decreased upon drying of THC chemotype. Moderate increase in β-caryophyllene and caryophyllene oxide was observed. However, there was no detectable change in the percentage of monoterpenes and sesquiterpenes content in both the intermediate type and CBD chemotype upon drying. The insecticidal activity of the volatile oils was evaluated. The oil obtained from the fresh and dried high CBD cannabis showed good biting deterrent activity at 10 ug/cm2 compared with N,N-diethyl-meta-toluamide at 4.78 µg/cm2, and good larvicidal activity.
中文翻译:
大麻c血吸虫新鲜和风干芽挥发油的化学成分,杀虫和驱虫活性
通过加氢蒸馏制备3种不同大麻品种的新鲜和风干芽的挥发油,即高大麻二酚(CBD)化学型,中度CBD /四氢大麻酚(THC)化学型和高THC化学型。挥发油的气相色谱分析结果鉴定出71种化合物,其中33种为单萜,而38种为倍半萜。从THC化学型获得的挥发油显示出倍半萜与单萜含量的比例增加。THC化学型干燥后,萜品油烯的含量显着降低。观察到β-石竹烯和氧化石竹烯适度增加。但是,在中间型和CBD化学型中,干燥后单萜和倍半萜含量的百分比均未检测到变化。评价了挥发油的杀虫活性。从新鲜和干燥的高CBD大麻中获得的油在10 ug / cm的压力下表现出良好的抑制作用2相比Ñ,ñ -二乙基间甲苯甲酰胺在4.78微克/厘米2,和良好的杀幼虫活性。