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Antimycobacterial Activity of Milemarinol, a New Squalene-Type Triterpene, and Other Isolate?
Natural Product Communications ( IF 1.5 ) Pub Date : 2020-05-18 , DOI: 10.1177/1934578x20925589
Samyra I. S. Boeno 1 , Michel de S. Passos 1 , Mariana Félix 1 , Sanderson D. Calixto 2 , Almir R. C. Júnior 3 , Lara F. Barbosa Siqueira 4 , Michelle F. Muzitano 5 , Raimundo Braz-Filho 1, 6 , Ivo J. Curcino Vieira 1
Affiliation  

A new triterpene, named milemaronol (1), was isolated from Homalolepis suffruticosa Engl., Simaroubaceae, along with 10 known metabolites, chaparrinone (2), scopoletin (3), 5-methoxycanthin-6-one (4), eurylene (5), hispidol A (6), hispidol B (7), nilocitine (8), α-dihydronylocytine (9), β-dihydronylocytine (10), and teurilene (11). These compounds were characterized based on their spectral data, mainly 1D (1H, 13C-APT) and 2D (1H-1H-COSY, NOESY, HSQC, HMBC) NMR and their mass spectra (HR-ESI-MS), in comparison with data from the literature. Compounds 1 to 6, 8, and 9 were evaluated for their antimycobacterial activity against 2 strains (H37Rv and M299).



中文翻译:

Milemarinol,新的角鲨烯型三萜和其他分离物的抗分枝杆菌活性?

Simaroubaceae的Homalolepis suffruticosa Engl。中分离出一种新的三萜烯,命名为milemaronol(1),以及10种已知的代谢物,查帕瑞酮(2),大戟素(3),5-甲氧基天花素-6-一(4),二烯(5)),组氨酸A(6),组氨酸B(7),尼罗西汀(8),α-二氢顺式鸟碱(9),β-​​二氢顺式鸟碱(10)和丁草烯(11)。这些化合物根据其光谱数据进行表征,主要是1D(1 H,13 C-APT)和2D(1H- 1 H-COSY,NOESY,HSQC,HMBC)NMR和它们的质谱(HR-ESI-MS),与来自文献的数据进行比较。化合物168,和9中它们对2个菌株(H37Rv株和M299)抗分支杆菌活性进行评价。

更新日期:2020-07-13
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