Piceid, stilbenoid glucoside, is a representative resveratrol derivative. Because of a high tyrosinase inhibitory activity of piceid through resveratrol derivatives, transdermal delivery of piceid has been desired for taking advantage of the activity. Here we successfully prepared composite nanoparticles composed of anionic phospholipid of 1,2-dipalmitoyl-sn-glycero-3-phosphorylglycerol (DPPG) and piceid by mixing them in water and a subsequent heating/cooling process. When small-sized fluorescently labeled DPPG-piceid (DPPG-^FLpiceid) nanoparticles were added to rat skin tissue, ^FLpiceid molecules were localized in stratum corneum.

Piceid，stilbenoid苷，是代表性的白藜芦醇衍生物。由于白藜芦醇通过白藜芦醇衍生物具有很高的酪氨酸酶抑制活性，因此需要利用该活性来透皮递送白藜芦醇。在这里，我们通过在水中混合并随后进行加热/冷却过程，成功制备了由1,2-二棕榈酰-sn-甘油-3-磷酸甘油酯（DPPG）和磷脂形成的阴离子磷脂组成的复合纳米颗粒。当将小尺寸的荧光标记的DPPG-哌啶（DPPG- ^FL哌啶）纳米颗粒添加到大鼠皮肤组织中时，^FL哌啶分子位于角质层中。