Introduction. Tooth loss is associated with poor oral hygiene. During insufficient oral sanitation, focal infection and inflammation can occur and these reactions may induce systemic inflammation. Systemic inflammatory reaction may be related to the degeneration of dopamine neurons in the substantia nigra. We hypothesized that tooth loss is related to increased risk of new-onset Parkinson’s disease. Methods. Between 2003 and 2006, we included 153,165 participants from the national health insurance system-health screening cohort in Korea. The incidence of new-onset Parkinson’s disease was defined as International Classification of Diseases-10 code “G20,” accompanying the prescription records for any anti-Parkinson’s disease medication. Results. Approximately 19.9% of the included participants had periodontal disease. After a median duration of 10.4 years, 1,227 (0.8%) cases of new-onset Parkinson’s disease were noted. The number of tooth loss was positively related to an increased risk of new-onset Parkinson’s disease. Contrastingly, the frequency of tooth brushings and dental clinic visits for any causes as well as competent dental care were negatively related to the development of new-onset Parkinson’s disease. In multivariable analysis, the number of tooth loss (≥15) was positively related to new-onset Parkinson’s disease development (hazard ratio: 1.38, 95% confidence interval (1.03–1.85), , for trend = 0.043) after adjusting variables. Conclusion. Our study demonstrated that the number of tooth loss was positively correlated with a higher risk of new-onset Parkinson’s disease development in a longitudinal study setting. Increased number of tooth loss may be an important risk indicator of new-onset Parkinson’s disease.

中文翻译：

---

牙齿脱落与新发帕金森病的关联：一项基于全国人口的队列研究。

简介。牙齿脱落与口腔卫生差有关。在口腔卫生不足的情况下，可能会发生局灶性感染和炎症，这些反应可能会引起全身炎症。全身炎症反应可能与黑质多巴胺神经元的退化有关。我们假设牙齿脱落与新发帕金森病的风险增加有关。方法。2003 年至 2006 年间，我们纳入了来自韩国国家健康保险系统健康筛查队列的 153,165 名参与者。新发帕金森病的发病率被定义为国际疾病分类 10 代码“G20”，并附有任何抗帕金森病药物的处方记录。结果. 大约 19.9% 的参与者患有牙周病。在 10.4 年的中位持续时间后，记录了 1,227 例（0.8%）新发帕金森病病例。牙齿脱落的数量与新发帕金森病的风险增加呈正相关。相比之下，刷牙频率和因任何原因就诊的牙科诊所以及合格的牙科护理与新发帕金森病的发展呈负相关。在多变量分析中，牙齿脱落的数量（≥15）与新发帕金森病的发展呈正相关（风险比：1.38，95% 置信区间（1.03-1.85），, 对于趋势 = 0.043) 调整变量后。结论。我们的研究表明，在纵向研究环境中，牙齿脱落的数量与新发帕金森病发展的风险较高呈正相关。牙齿脱落数量的增加可能是新发帕金森病的重要风险指标。