It has been established that poor outcomes in ischemic stroke patients are associated with the post-reperfusion inflammatory response and up-regulation of TLR4. Therefore, suppression of the TLR4 signaling pathway constitutes a potential neuroprotective therapeutic strategy. Schisandrin B, a compound extracted from Schisandra chinensis, has been shown to possess anti-inflammatory and neuroprotective properties. However, the mechanism remains unclear. In the present study, the therapeutic effect of schisandrin B was assessed following cerebral ischemia and reperfusion (I/R) injury in a model of middle cerebral artery occlusion and reperfusion (MCAO/R) in rats. The effects of schisandrin B were investigated with particular emphasis on TLR4 signal transduction and on the inflammatory response. Schisandrin B treatment conferred significant protection against MCAO/R injury, as evidenced by decreases in infarct volume, neurological score, and the number of apoptotic neurons and inflammatory signaling molecules.

Abbreviations

I/R: schemia/reperfusion; IL: interleukin; MCAO/R: middle cerebral artery occlusion and reperfusion; NF-κB: nuclear; TLR4: Toll-like receptor 4; TNF-α: tumor necrosis factor-α

中文翻译：

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五味子素B通过抑制TLR4 /NF-κB信号通路改善大鼠脑缺血并减少再灌注损伤。

已经确定，缺血性中风患者的不良预后与再灌注后炎症反应和TLR4上调有关。因此，TLR4信号通路的抑制构成潜在的神经保护性治疗策略。五味子素B，从五味子中提取的化合物已显示具有抗炎和神经保护特性。但是，机制尚不清楚。在本研究中，在大鼠大脑中动脉阻塞和再灌注模型（MCAO / R）中，评估了五味子素B在脑缺血和再灌注（I / R）损伤后的治疗效果。研究了五味子素B的作用，尤其着重于TLR4信号转导和炎症反应。五味子叶素B治疗对MCAO / R损伤具有显着的保护作用，如梗死体积，神经系统评分以及凋亡神经元和炎性信号分子数量的减少所证明。

缩略语

I / R：缺血/再灌注；IL：白介素；MCAO / R：大脑中动脉闭塞和再灌注；NF-κB：核；TLR4：Toll样受体4；TNF-α：肿瘤坏死因子-α