Abstract

The methanolic extract of the waste seeds of Sesamum indicum L. (Pedaliaceae) was subjected to chromatographic fractionation; it led to the isolation of an alkyl benzene identified as 1,3-bis (pentadecyl)benzene (1) along with three known fatty acids: oleic acid (2), linoleic acid (3), and palmitic acid (4); one monosaturated cardanol, 3-pentadecylphenol (5) and two phytosteroids identified as sitostanol (6) and campestanol (7). The structures of these compounds were elucidated by chemical and spectroscopic analyses. Compounds 1, 5 and 6 were evaluated against protozoan parasites. Compound 1 moderately inhibited the promastigote form of Leishmania donovani LG13 with IC₅₀ equal to 16.9 μM.

摘要

芝麻（Pedaliaceae）废种子甲醇提取物经色谱分离；它导致分离出一种烷基苯，鉴定为 1,3-双（十五烷基）苯 ( 1 ) 以及三种已知的脂肪酸：油酸 ( 2 )、亚油酸 ( 3 ) 和棕榈酸 ( 4 )；一种单饱和腰果酚、3-十五烷基苯酚 ( 5 ) 和两种植物甾醇，鉴定为谷甾烷醇 ( 6 ) 和菜油甾醇 ( 7 )。通过化学和光谱分析阐明了这些化合物的结构。化合物1，5和6对原生动物寄生虫进行了评估。化合物1中度抑制Leishmania donovani LG13的前鞭毛体形式，IC ₅₀等于 16.9 μM。