Abstract

Natural products, especially plants, have been investigated as sources of new substances with antimicrobial properties. In this context, the Myrcia genus is extensively researched for presenting such activities. This work aims to evaluate the antifungal, antibacterial, and antioxidant properties of extracts and fractions of stems of Myrcia hatschbachii, also to characterize two phenolic compounds. The antibacterial and antifungal activities were assessed by using the broth microdilution method. The ethyl acetate fraction (FGA) inhibited the growth of Candida albicans at a Minimum Inhibitory Concentration (MIC) of 15.6 µg/mL, presented 40% of phenolic compounds in its composition, obtained the most significant results in antioxidant methods (DPPH, FRAP, ABTS), besides the identification of ellagic and 3-O-methyl ellagic acids by NMR. Considering the relevant antifungal activity revealed by the fraction, new studies can be carried out to encourage the continuous search for antifungal alternatives.

摘要

天然产物，尤其是植物，已被研究作为具有抗菌特性的新物质的来源。在这种情况下，对Myrcia属进行了广泛的研究以展示此类活动。这项工作旨在评估Myrcia hatschbachii茎提取物和级分的抗真菌、抗菌和抗氧化特性，同时表征两种酚类化合物。通过使用肉汤微量稀释法评估抗菌和抗真菌活性。乙酸乙酯组分 (FGA) 抑制白色念珠菌的生长在 15.6 µg/mL 的最低抑菌浓度 (MIC) 下，其组成中存在 40% 的酚类化合物，除了鉴定鞣花和 3-O-核磁共振甲基鞣花酸。考虑到该部分揭示的相关抗真菌活性，可以进行新的研究以鼓励持续寻找抗真菌替代品。