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A new steroid with 7β,8β-epoxidation from the deep sea-derived fungus Aspergillus penicillioides SD-311
Journal of Asian Natural Products Research ( IF 1.3 ) Pub Date : 2020-07-13 , DOI: 10.1080/10286020.2020.1791096
Lu-Ping Chi 1, 2 , Sui-Qun Yang 1, 3, 4 , Xiao-Ming Li 1, 3, 4 , Xiao-Dong Li 1 , Bin-Gui Wang 1, 3, 4 , Xin Li 1, 3, 4
Affiliation  

Abstract

7β,8β-epoxy-(22E,24R)-24-methylcholesta-4,22-diene-3,6-dione (1), a new steroid, along with five known analogues (26), was isolated from the deep sea-derived fungus, Aspergillus penicillioides SD-311. Strikingly, 1 possessed a rare 7,8-epoxidation moiety. Meanwhile, this is the first time to report natural products from this fungus species. The structures were established by extensive spectroscopic analysis. The absolute configuration was determined by X-ray diffraction experiments. Compound 1 showed antibacterial activity against Vibrio anguillarum with MIC value of 32.0 µg/mL, while 2 displayed inhibitions against Edwardsiella tarda and Micrococcus luteus with MIC values both of 16 µg/mL.



中文翻译:

来自深海真菌青霉曲霉 SD-311 的具有 7β,8β-环氧化作用的新型类固醇

摘要

7β,8β-epoxy-(22 E ,24 R )-24-methylcholesta-4,22-diene-3,6-dione ( 1 ),一种新的类固醇,以及五种已知的类似物 ( 26 ),被分离出来来自深海来源的真菌,青霉曲霉SD-311。引人注目的是,1拥有罕见的 7,8-环氧化部分。同时,这是首次报道这种真菌物种的天然产物。这些结构是通过广泛的光谱分析建立的。通过X射线衍射实验确定绝对构型。化合物1显示出对鳗弧菌的抗菌活性,MIC 值为 32.0 µg/mL,而化合物2显示出对迟发性爱德华氏菌藤黄微球菌的抑制作用,MIC 值均为 16 µg/mL。

更新日期:2020-07-13
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