Abstract

7β,8β-epoxy-(22E,24R)-24-methylcholesta-4,22-diene-3,6-dione (1), a new steroid, along with five known analogues (2–6), was isolated from the deep sea-derived fungus, Aspergillus penicillioides SD-311. Strikingly, 1 possessed a rare 7,8-epoxidation moiety. Meanwhile, this is the first time to report natural products from this fungus species. The structures were established by extensive spectroscopic analysis. The absolute configuration was determined by X-ray diffraction experiments. Compound 1 showed antibacterial activity against Vibrio anguillarum with MIC value of 32.0 µg/mL, while 2 displayed inhibitions against Edwardsiella tarda and Micrococcus luteus with MIC values both of 16 µg/mL.

摘要

7β,8β-epoxy-(22 E ,24 R )-24-methylcholesta-4,22-diene-3,6-dione ( 1 )，一种新的类固醇，以及五种已知的类似物 ( 2 – 6 )，被分离出来来自深海来源的真菌，青霉曲霉SD-311。引人注目的是，1拥有罕见的 7,8-环氧化部分。同时，这是首次报道这种真菌物种的天然产物。这些结构是通过广泛的光谱分析建立的。通过X射线衍射实验确定绝对构型。化合物1显示出对鳗弧菌的抗菌活性，MIC 值为 32.0 µg/mL，而化合物2显示出对迟发性爱德华氏菌和藤黄微球菌的抑制作用，MIC 值均为 16 µg/mL。