Abstract

Objective

Motor neuron disease (MND) is a rapidly progressive neurodegenerative condition with no known cure. MND can affect every aspect of a person’s life and has been associated with a wide range of psychological difficulties, which can occur from pre-diagnosis through to the condition’s later stages. However, very little research has been conducted on psychological interventions for people with MND (pwMND). This paper aimed to provide the first review specifically targeting psychological interventions in MND and offer potential directions for future research. Methods: A scoping review was carried out across five major databases (PubMed, PsycINFO, CINAHL, Academic Search Ultimate, and Cochrane Library) until 1st of March 2020. Results: From an initial return of 1278 citations, 10 papers were included in the review. These included three randomized controlled trials (RCTs), two quasi-experiments, three uncontrolled pretest–post-test designs, one single case study, and one qualitative secondary analysis. The existing studies focused on a limited number of psychological outcomes and did not take into account site of MND onset or level of depression/anxiety before intervention. Implications for clinical practice are discussed and suggestions for future research are provided. Conclusions: The literature on psychological interventions is still extremely sparse. Mindfulness-based stress reduction (MBSR) and cognitive behavioral therapy (CBT) based on the stress-coping model show promise in RCTs, but require further evaluation. The need for further development and evaluation of psychological interventions to improve the well-being of pwMND cannot be overstated, particularly as the struggle toward the discovery of an effective treatment for MND continues.

中文翻译：

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运动神经元疾病患者的心理干预：范围审查

摘要

客观的

运动神经元病 (MND) 是一种快速进展的神经退行性疾病，尚无治愈方法。MND 会影响一个人生活的方方面面，并与广泛的心理困难有关，这些困难可能发生在从诊断前到病情的后期阶段。然而，关于 MND (pwMND) 患者心理干预的研究很少。本文旨在提供第一篇专门针对 MND 心理干预的综述，并为未来的研究提供潜在的方向。方法：截至 2020 年 3 月 1 日，对五个主要数据库（PubMed、PsycINFO、CINAHL、Academic Search Ultimate 和 Cochrane Library）进行了范围界定审查。结果：从最初返回的 1278 次引用中，有 10 篇论文被纳入审查。其中包括三项随机对照试验 (RCT)、两项准实验、三项不受控制的前后测设计、一项单一案例研究和一项定性二次分析。现有的研究侧重于有限数量的心理结果，并没有考虑到 MND 的发病部位或干预前的抑郁/焦虑程度。讨论了对临床实践的影响，并提供了对未来研究的建议。结论：关于心理干预的文献仍然极其稀少。基于压力应对模型的正念减压 (MBSR) 和认知行为疗法 (CBT) 在 RCT 中显示出前景，但需要进一步评估。进一步发展和评估心理干预措施以改善 pwMND 的福祉的必要性怎么强调都不为过，尤其是在寻找有效治疗 MND 的斗争仍在继续的情况下。