Ferroptosis is mechanism for non-apoptotic, iron-dependent, oxidative cell death that is characterized by glutathione consumption and lipid peroxides accumulation. Ferroptosis is crucially involved in neurological diseases, including neurodegeneration, stroke and neurotrauma. This review provides detailed discussions of the ferroptosis mechanisms in these neurological diseases. Moreover, it summarizes recent drugs that target ferroptosis for neurological disease treatment. Furthermore, it compares the differences and relationships among the various cell death mechanisms involved in neurological diseases. Elucidating the ferroptosis role in the brain can improve the understanding of neurological disease mechanism and provide potential prevention and treatment interventions for acute and chronic neurological diseases.

Ferroptosis是非凋亡，铁依赖性氧化细胞死亡的机制，其特征在于谷胱甘肽的消耗和脂质过氧化物的积累。Ferroptosis至关重要地参与了神经系统疾病，包括神经变性，中风和神经创伤。这篇综述提供了关于这些神经系统疾病中促铁作用机理的详细讨论。而且，它总结了针对神经病治疗的针对肥大症的最新药物。此外，它比较了神经疾病涉及的各种细胞死亡机制之间的差异和关系。阐明大脑中的肥大症作用可以增进对神经系统疾病机制的了解，并为急性和慢性神经系统疾病提供潜在的预防和治疗干预措施。