Play, but not observing play, engages rat medial prefrontal cortex,European Journal of Neuroscience

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Play, but not observing play, engages rat medial prefrontal cortex
European Journal of Neuroscience ( IF 2.7 ) Pub Date : 2020-07-13 , DOI: 10.1111/ejn.14908
Miguel Concha‐Miranda _{1,

2} , Konstantin Hartmann ₂ , Annika Reinhold ₂ , Michael Brecht _{2,

3} , Juan I. Sanguinetti-Scheck ₂

Affiliation

Rats have elaborate cognitive capacities for playing Hide & Seek. Playing Hide & Seek strongly engages medial prefrontal cortex and the activity of prefrontal cortex neurons reflects the structure of the game. We wondered if prefrontal neurons would also show a mirroring of play‐related neural activity. Specifically, we asked how does the activity in the rat medial prefrontal cortex differ when the animal plays itself versus when it observes others playing. Consistent with our previous work, when the animal plays itself we observed medial prefrontal cortex activity that was sharply locked to game events. Observing play, however, did not lead to a comparable activation of rat medial prefrontal cortex. Firing rates during observing play were lower than during real play. The modulation of responses in medial prefrontal cortex by game events was strong during playing Hide & Seek, but weak during observing Hide & Seek. We conclude the rat prefrontal cortex does not mirror play events under our experimental conditions.

中文翻译：

玩耍而不是观察玩耍会吸引大鼠内侧前额叶皮层

老鼠具有玩捉迷藏的精细认知能力。玩“捉迷藏”游戏会强烈参与内侧前额叶皮层，而前额叶皮层神经元的活动反映了游戏的结构。我们想知道前额神经元是否也会显示与游戏相关的神经活动的镜像。具体来说，我们询问当动物玩耍时和观察其他人玩耍时，大鼠前额内侧皮层中的活动有何不同。与我们之前的工作一致，当动物玩耍时，我们观察到内侧前额叶皮层活动已被游戏活动完全锁定。然而，观察游戏并没有导致大鼠内侧前额叶皮层的可比激活。观察比赛中的射击率低于真实比赛中的射击率。在玩“捉迷藏”过程中，游戏事件对内侧前额叶皮层反应的调节作用很强，但在观察“捉迷藏”过程中作用却很弱。我们得出结论，在我们的实验条件下，大鼠前额叶皮层并不反映游戏事件。

更新日期：2020-07-13

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