Compared to other seizure types, generalized tonic‐clonic (GTC) seizures may be disproportionately related to increased morbidity, and reducing seizure frequency could translate into improvements across measures of morbidity in medically treated patients with drug‐resistant epilepsy (DRE). The primary objective of this analysis was to quantify the burden of patients with DRE who experience GTC seizures (GTC+) compared to patients with DRE who do not experience GTC seizures (GTC−).

中文翻译：

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量化耐药性癫痫患者全身强直阵挛发作的负担

与其他癫痫类型相比，全身性强直阵挛 (GTC) 癫痫发作可能与发病率增加不成比例，降低癫痫发作频率可以转化为药物治疗耐药性癫痫 (DRE) 患者的发病率指标的改善。该分析的主要目的是量化经历 GTC 癫痫发作 (GTC+) 的 DRE 患者与未经历 GTC 癫痫发作 (GTC-) 的 DRE 患者的负担。