Mimochrome, a metalloporphyrin-based catalytic Swiss knife†.,Biotechnology and Applied Biochemistry

当前位置： X-MOL 学术 › Biotechnol. Appl. Bioc. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Mimochrome, a metalloporphyrin-based catalytic Swiss knife†.
Biotechnology and Applied Biochemistry ( IF 3.2 ) Pub Date : 2020-07-13 , DOI: 10.1002/bab.1985
Linda Leone ₁ , Marco Chino ₁ , Flavia Nastri ₁ , Ornella Maglio _{1,

2} , Vincenzo Pavone ₁ , Angela Lombardi ₁

Affiliation

Over the years, mimochromes, a class of miniaturized porphyrin‐based metalloproteins, have proven to be reliable but still versatile scaffolds. After two decades from their birth, we retrospectively review our work in mimochrome design and engineering, which allowed us developing functional models. They act as electron‐transfer miniproteins or more elaborate artificial metalloenzymes, endowed with peroxidase, peroxygenase, and hydrogenase activities. Mimochromes represent simple yet functional synthetic models that respond to metal ion replacement and noncovalent modulation of the environment, similarly to natural heme‐proteins. More recently, we have demonstrated that the most active analogue retains its functionality when immobilized on nanomaterials and surfaces, thus affording bioconjugates, useful in sensing and catalysis. This review also briefly summarizes the most important contributions to heme‐protein design from leading groups in the field.

中文翻译：

Mimochrome，一种基于金属卟啉的催化瑞士刀†。

多年来，已证明mimochromes是一类基于卟啉的微型金属蛋白，是可靠的但仍具有通用性的支架。从他们出生的二十年后，我们回顾了我们在mimochrome设计和工程方面的工作，这使我们能够开发功能模型。它们充当电子转移性小蛋白或更复杂的人造金属酶，具有过氧化物酶，过氧化酶和氢化酶的活性。Mimochromes代表简单而实用的合成模型，与天然血红蛋白类似，它们对金属离子置换和环境的非共价调节具有响应。最近，我们已经证明，最具活性的类似物固定在纳米材料和表面上后仍保留其功能，从而提供了可用于传感和催化的生物共轭物。

更新日期：2020-09-10

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11